6957-15-9

Usage

Uses

Used in Organic Synthesis:
N-(2,2-diethoxyethyl)pyridine-2-methylamine is used as a reagent and intermediate in organic synthesis. Its unique structure allows it to participate in various chemical reactions, contributing to the synthesis of complex organic molecules.
Used in Pharmaceutical Industry:
N-(2,2-diethoxyethyl)pyridine-2-methylamine has been studied for its potential applications in pharmaceuticals. Its chemical properties and structure make it a valuable compound for the development of new drugs and therapeutic agents.
Used in Agrochemicals:
N-(2,2-diethoxyethyl)pyridine-2-methylamine has also been explored for its potential use in agrochemicals. Its unique structure and properties may contribute to the development of new pesticides, herbicides, or other agricultural chemicals to improve crop protection and yield.

InChI:InChI=1/C12H20N2O2/c1-3-15-12(16-4-2)10-13-9-11-7-5-6-8-14-11/h5-8,12-13H,3-4,9-10H2,1-2H3

Upstream product

• 6190-94-9 (2,2-diethoxy-ethyl)-pyridin-2-ylmethylene-amine 
• 1121-60-4 pyridine-2-carbaldehyde 
• 645-36-3 2,2-diethoxy-ethanamine 

Relevant academic research and scientific papers

ALPHA HELIX MIMETICS AND METHODS RELATING THERETO

Alpha-helix mimetic structures and compounds represented by the formula (I) wherein the general formula and the definition of each symbol are as defined in the specification, a chemical library relating thereto, and methods relating thereto, are disclosed. Applications of these compounds in the treatment of medical conditions, e.g., cancer diseases, fibrotic diseases, and pharmaceutical compositions comprising the mimetics are further disclosed.

Inhibitors of dopamine β-hydroxylase. 3. Some 1-(pyridylmethyl)imidazole-2 thiones

The 1-benzylimidazole-2-thione moiety has been previously shown by Kruse et al. to be broadly associated with dopamine β-hydroxylase (DBH) inhibitory activity both in vitro and in vivo in spontaneously hypertensive rats (SHR). An extension of structure-activity studies to 1-(pyridylmethyl)- and 1-(oxypyridylmethyl)imidazole-2-thiones is reported here in an attempt to exploit the pH differential that exists across the chromaffin vesicle membrane. We hypothesized that the weakly basic pyridyl compounds would diffuse into the acidic vesicles in their neutral forms where protonation and concentration would occur to enhance their in vivo effectiveness as inhibitors. To test this hypothesis, isomeric 2-,3- and 4-(1-pyridylmethyl)imidazole-2-thiones were synthesized from the appropriate pyridinecarboxaldehydes by reductive alkylation of aminoacetaldehyde dialkyl acetal followed by imidazole-2-thione formation using acidic potassium thiocyanate. Related oxypyridyl compounds were synthesized by first preparing the appropriate aldehyde intermediate followed by conversion to the imidazole-2-thione by the same procedure. The unsubstituted pyridylmethyl compounds showed modest DBH inhibition in vitro but, consistent with a transport-mediated increase in observed potency, showed significant effects in vivo to increase the vascular ratio of dopamine to norepinephrine and to lower blood pressure.