6958-90-3Relevant academic research and scientific papers
Cooperative N-Heterocyclic Carbene/Nickel-Catalyzed Hydroacylation of 1,3-Dienes with Aldehydes in Water
Gao, Zhong-Hua,Han, You-Feng,Liu, Hao,Wang, Congyang,Ye, Song,Zhang, Chun-Lin
, p. 1657 - 1663 (2022/01/28)
The cooperative N-heterocyclic carbene/nickel-catalyzed redox-neutral hydroacylation of 1,3-dienes with aldehydes in water was reported. A wide range of aliphatic and aromatic aldehydes were directly coupled with 1,3-dienes, providing synthetically useful β,γ-unsaturated ketones or the corresponding ketones after hydrogenation in moderate to high yields and high atom economy. This protocol first demonstrated the compatibility of NHC catalysis with nickel catalysis. Water was used as the sole solvent, which is rarely reported in a cooperative metal/organic catalytic system.
Synthesis of 2,5-dihydrofurans via alkylidene carbene insertion reactions
Walker, Louise F.,Bourghida, Ahmed,Connolly, Stephen,Wills, Martin
, p. 965 - 981 (2007/10/03)
The insertion reaction of alkylidene carbenes is demonstrated to be an effective method for the synthesis of 2,5-dihydrofuran ring systems. The best results have been obtained on substrates containing electron-withdrawing substituents, which appear less prone to the competing rearrangement reaction. This insight has led to the development of a new method for the synthesis of the core structure of the squalestatin-zaragozic acid natural products.
