6959-56-4Relevant academic research and scientific papers
Nucleophilic substitution of chlorine with hydrazine and methylhydrazine in chlorinated pyridazines and pyridazones
Baranov,Tsypin,Malin,Laskin
, p. 1997 - 2000 (2007/10/03)
The reactions of methylhydrazine and hydrazine hydrate with chlorinated pyridazines and pyridazones were studied.
A novel and practical animation of 4,5-dichloropyridazin-3-ones via reduction with hydrazine hydrate
Cao, Song,Qian, Xuhong,Song, Gonghua,Huang, Xiayu
, p. 54 - 55 (2007/10/03)
A novel and simple protocol: the direct amination of 4,5-dichloropyridazinones can be carried out in hydrazine hydrate under mild conditions. 4-Chloro-5-hydrazinopyridazin-3-ones serves as a key intermediate in this reduction.
Synthesis of novel pyridazine acyclonucleosides
Cho,Chung,Choi,Kim,Yoon
, p. 1199 - 1208 (2007/10/02)
Some pyridazine acyclonucleosides containing hydroxymethyl and 4-hydroxybutyl groups as an alkanol side chain were prepared. Nucleophilic displacement of N1-alkyl-4,5-dichloropyridazin-6-ones is discussed.
SYNTHESIS OF PYRAZOLOPYRIDAZINE DERIVATIVES- TWO COMPARABLE APPROACHES, RING CONTRACTION THROUGH EXTRUSION OF SULPHUR AND PHOTOCHEMICAL CYCLISATION
Kaji, Kenji,Nagashima, Hiromu,Ohta, Yusho,Nagao, Sigeto,Hirose, Yoshihiko,Oda, Hirohisa
, p. 479 - 484 (2007/10/02)
Ring contraction of 7-substituted 2-phenyl-4H-pyridazinothiadiazin-8(7H)-ones (5a-d) to 5-substituted 3-phenyl-1H-pyrazolopyridazin-4(5H)-ones (7a-d), through base-induced extrusion of sulphur, is described.Similar reactions proceed, not only on the 4-acetyl derivatives (4a-d) in basic media, but on 5a and the 4-methyl derivative (6a) thermally.Probable mechanism of these reactions are discussed.A comparable approach to the ring contraction, photochemical cyclisation of 2-substituted 5-(1-alkyl-2-benzylidenehydrazino)-4-chloro-3(2H)-pyridazinones (9a-e) to the corresponding 1-alkylpyrazolo-pyridazinone derivatives (8a-e) is also performed.
