1677-79-8

Usage

Uses

Used in Pharmaceutical Industry:
4-CHLORO-3(2H)-PYRIDAZINONE is used as an intermediate in the synthesis of various pharmaceuticals for its ability to be incorporated into the molecular structures of drugs, enhancing their therapeutic properties and effectiveness.
Used in Agrochemical Industry:
4-CHLORO-3(2H)-PYRIDAZINONE is used as a building block in the development of agrochemicals, such as pesticides and herbicides, due to its reactivity and potential to improve the performance of these products.
Used in Organic Chemistry Research:
4-CHLORO-3(2H)-PYRIDAZINONE is utilized as a versatile chemical in the field of organic chemistry research, allowing scientists to explore its properties and reactivity in the synthesis of new compounds and materials.
Used in Production of Other Organic Compounds:
4-CHLORO-3(2H)-PYRIDAZINONE is used as a key component in the production of a wide range of organic compounds, contributing to the development of various industrial and consumer products.

Upstream product

• 1232361-90-8 4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-2H-pyridazin-3-one 
• 6959-56-4 4-Chloro-5-hydrazino-3(2H)-pyridazinone 
• 1314898-43-5 4-chloro-5-hydrazinyl-3(2H)-pyridazinone 

Downstream Products

• 1677-80-1 3,4-dicholoropyridazine 
• 69207-44-9 4-chloro-2-methyl-pyridazine-3(2H)-one 
• 98441-29-3 4-phenyl-2,3-dihydropyridazin-3-one 

Relevant academic research and scientific papers

A 3,4- [...] method for the synthesis of

The invention discloses a novel synthesis method of 3,4-dichloropyridazine. The 3,4-dichloropyridazine 4 is prepared through reaction between a compound 3 and POCl3 in an isopropanol solvent, the compound 3 is prepared through reaction between a compound 2 and MnO2 in a tetrahydrofuran solvent, and the compound 2 is prepared through reaction between a compound 1 and hydrazine hydrate in an acetonitrile solvent, wherein preferred conditions are as follows: a mol ratio of the hydrazine hydrate to the compound 1 is 1.1 to 1, the reaction temperature is 25-30 DEG C, the time is 6h; a mol ratio of MnO2 to the compound 2 is 4 to 1, the reaction temperature is 25 DEG C, the time is 8h; a mol ratio of the POCl3 to the compound 2 is 2.5 to 1, the reflowing reaction temperature is 80 DEG C, and the time is 3h. The synthesis method has the advantages that the raw materials are easily available, reaction conditions are mild, operability in post-treatment is good, the yield is relatively high, the production is easily enlarged, and thus the novel synthesis method is especially suitable for industrial large-scale production.

HETEROCYCLIC ANTIVIRAL COMPOUNDS

Compounds having the formula I wherein R1, R2, R3, R4, and R5 are as defined herein are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for treating an HCV in

HETEROCYCLIC ANTIVIRAL COMPOUNDS

Compounds having the formula I wherein wherein R1, R2, R3b, R4a, R4b, R4c and as defined herein are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods

HETEROCYCLIC ANTIVIRAL COMPOUNDS

Compounds having the formula I wherein R1, R2, R3, R4, R5a, R5b, R5c and R6 are as defined herein are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are

HETEROCYCLIC ANTIVIRAL COMPOUNDS

Compounds having the formula I wherein wherein R1, R2, R3, R4, X1, X2, X3 and X4 and as defined herein are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for treating an HCV infection and inhibiting HCV replication.

HETEROCYCLIC ANTIVIRAL COMPOUNDS

Compounds having the formula I wherein A, R1, R2, R3, R4a, R4b, R4c, R5, R6, R7a, R7b, Ar1, Rc, Rd, Re/sup