1677-79-8

Basic information

• Product Name: 4-CHLORO-3(2H)-PYRIDAZINONE
• Synonyms: 4-CHLORO-3(2H)-PYRIDAZINONE;3(2H)-Pyridazinone,4-chloro-(;4-Chloropyridazin-3(2H)-one;4-Chloro-3-pyridazone;4-chloro-2,3-dihydropyridazin-3-one;4-Chloro-2H-pyridazin-3-one;4-Chloropyridazin-3-one
• CAS NO: 1677-79-8
• Molecular Formula: C₄H₃ClN₂O
• Molecular Weight: 130.53
• EINECS: 200-001-2
• Mol File: 1677-79-8.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Density: 1.55±0.1 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 9.80±0.40(Predicted)
• CAS DataBase Reference: 4-CHLORO-3(2H)-PYRIDAZINONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-3(2H)-PYRIDAZINONE(1677-79-8)
• EPA Substance Registry System: 4-CHLORO-3(2H)-PYRIDAZINONE(1677-79-8)

Safety Data

• Hazardous Substances Data: 1677-79-8(Hazardous Substances Data)

Usage

General Description

4-CHLORO-3(2H)-PYRIDAZINONE is a chemical compound with the molecular formula C4H3ClN2O. It is an organic compound belonging to the class of pyridazinones, which are heterocyclic compounds containing a pyridazine ring. 4-CHLORO-3(2H)-PYRIDAZINONE is a chlorinated derivative of pyridazinone, with a chloro group attached to the fourth carbon atom. It has various industrial applications, including its use as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. 4-CHLORO-3(2H)-PYRIDAZINONE is a valuable building block in organic chemistry and is used in the production of a wide range of materials. Its properties and reactivity make it a versatile and important chemical in the field of industry and research.

Upstream product

• 1314898-43-5 4-chloro-5-hydrazinyl-3(2H)-pyridazinone 
• 6959-56-4 4-Chloro-5-hydrazino-3(2H)-pyridazinone 
• 1232361-90-8 4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-2H-pyridazin-3-one 

Downstream Products

• 1677-80-1 3,4-dicholoropyridazine 
• 98441-29-3 4-phenyl-2,3-dihydropyridazin-3-one 
• 69207-44-9 4-chloro-2-methyl-pyridazine-3(2H)-one 

Relevant articles and documents

A 3,4- [...] method for the synthesis of

The invention discloses a novel synthesis method of 3,4-dichloropyridazine. The 3,4-dichloropyridazine 4 is prepared through reaction between a compound 3 and POCl3 in an isopropanol solvent, the compound 3 is prepared through reaction between a compound 2 and MnO2 in a tetrahydrofuran solvent, and the compound 2 is prepared through reaction between a compound 1 and hydrazine hydrate in an acetonitrile solvent, wherein preferred conditions are as follows: a mol ratio of the hydrazine hydrate to the compound 1 is 1.1 to 1, the reaction temperature is 25-30 DEG C, the time is 6h; a mol ratio of MnO2 to the compound 2 is 4 to 1, the reaction temperature is 25 DEG C, the time is 8h; a mol ratio of the POCl3 to the compound 2 is 2.5 to 1, the reflowing reaction temperature is 80 DEG C, and the time is 3h. The synthesis method has the advantages that the raw materials are easily available, reaction conditions are mild, operability in post-treatment is good, the yield is relatively high, the production is easily enlarged, and thus the novel synthesis method is especially suitable for industrial large-scale production.

HETEROCYCLIC ANTIVIRAL COMPOUNDS

Compounds having the formula I wherein wherein R1, R2, R3b, R4a, R4b, R4c and as defined herein are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods

HETEROCYCLIC ANTIVIRAL COMPOUNDS

Compounds having the formula I wherein wherein R1, R2, R3, R4, X1, X2, X3 and X4 and as defined herein are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for treating an HCV infection and inhibiting HCV replication.