69626-31-9

Upstream product

• 3282-32-4 2-diazo-acetophenone 
• 107-19-7 propargyl alcohol 
• 28203-05-6 dimethoxy-2,2 phenyl-2 ethanol-1 
• 106-96-7 propargyl bromide 
• 98-86-2 acetophenone 

Downstream Products

• 1607002-65-2 (3S,Z)-4-(4-methoxybenzylidene)-3-phenyltetrahydrofuran-3-ol 
• 1607002-66-3 (3S,Z)-4-(4-fluorobenzylidene)-3-phenyltetrahydrofuran-3-ol 
• 76089-32-2 2-phenyl-2-(2-propynyloxymethyl)-1,3-dioxalane 

Relevant academic research and scientific papers

LiBF4: A mild and novel reagent for the O-H insertion reactions of α-diazoketones

Lithium tetrafluoroborate (10 mol%) is found to catalyze efficiently the O-H insertion reactions of α-diazoketones with various alcohols including benzylic, allylic, propargylic and cyclopropyl carbinols to produce the corresponding α-alkoxy ketones in excellent yields with high selectivity. A solution of 10 mol% of LiBF4 in acetonitrile provides a convenient reaction medium to carry out the O-H insertion reactions under mild and neutral conditions.

Condensation of chloromethyl propargyl ether with nitriles

Reactions of aromatic and aliphatic nitriles with chloromethyl propargyl ether in the presence of activated zinc followed by treatment with water in the presence of H3PMo12O40 afforded β-oxoethers.

Precatalyst-Enabled Selectivity: Enantioselective NiH-Catalyzed anti-Hydrometalative Cyclization of Alkynones to Endo- and Heterocyclic Allylic Alcohols

A highly enantioselective NiH-catalyzed hydrocyclization of alkynones with unparalleled anti- and endocyclic selectivities is described. The choice of the precatalysts has significant influence in tuning the regio- and enantioselectivity. Using Ni(OTs)su

Green Protocol for the O-H Insertion of α-Diazoketones with Alcohols and Water Using Ionic Liquid [Bmim]BF4

α-Diazoketones undergo readily O-H insertion reactions with alcohols and water in hydrophilic [bmim]BF4 ionic liquid in the absence of any acid catalyst to furnish α-alkoxy and α-hydroxy ketones in excellent yields under neutral conditions. The recovered ionic liquid can be easily reused in four to five cycles with consistent in activity. The use of ionic liquid helps to avoid the use of acid catalysts as well as environmentally unfavorable volatile organic solvents.