6966-37-6Relevant academic research and scientific papers
Design, Synthesis, and Biological Evaluation of Novel 1,2,4-Trioxanes as Potential Antimalarial Agents
Gupta, Amit K.,Varshney, Kanika,Kumar, Vivek,Srivastava, Kumkum,Pant, Aditya B.,Puri, Sunil K.,Saxena, Anil K.
, (2017/04/11)
A series of substituted 1,2,4-trioxanes were synthesized and evaluated for their antimalarial potential, in silico ADME properties and cytotoxicity on neuronal cell lines. Among the 15 synthesized substituted 1,2,4-trioxanes, two compounds (compound 15, IC50 = 25.71 nM; compound 21, IC50 = 19.6 nM) exhibited promising in vitro antimalarial potential comparable to those of the existing drugs chloroquine and artemisinin. Both of these compounds were found to be nontoxic up to 20 μM concentration in neuronal PC-12 cells. Compound 21 may serve as an optimized lead compound because of its less in vitro toxicity and lower probability to cross the blood brain barrier.
Synthesis of DL-hydroxybenzenamides as anticonvulsants
Meza-Toledo, Sergio E.,Yasutake-Kimoto, Liliana,Alcala-Renteria, Martha,Dominguez-Rodriguez, Miguel A.,Jaime-Rodriguez, Rodrigo,Nava-Arzaluz, Maria G.,Gutierrez-Laflor, Giovanna,Peralta-Cruz, Javier,Carvajal-Sandoval, Guillermo
, p. 105 - 110 (2008/09/19)
The anticonvulsant activity of some DL-hydroxybenzenamides is described. The following compounds from this series were prepared and tested: DL-2-hydroxy-2-(3′-bromophenyl)butyramide (4, CAS 620950-12-1), DL-2-hydroxy-2-(4′-bromophenyl)butyramide (5, CAS 6
