696603-96-0Relevant academic research and scientific papers
Development of a potent and selective FLT3 kinase inhibitor by systematic expansion of a non-selective fragment-screening hit
Nakano, Hirofumi,Hasegawa, Tsukasa,Imamura, Riyo,Saito, Nae,Kojima, Hirotatsu,Okabe, Takayoshi,Nagano, Tetsuo
, p. 2370 - 2374 (2016)
A non-selective inhibitor (1) of FMS-like tyrosine kinase-3 (FLT3) was identified by fragment screening and systematically modified to afford a potent and selective inhibitor 26. We confirmed that 26 inhibited the growth of FLT-3-activated human acute myeloid leukemia cell line MV4-11. Our design strategy enabled rapid development of a novel type of FLT3 inhibitor from the hit fragment in the absence of target-structural information.
Synthesis of N-arylindazole-3-carboxamide and N-benzoylindazole derivatives and their evaluation against α-MSH-stimulated melanogenesis
Arepalli, Sateesh Kumar,Lee, Chaerim,Jung, Jae-Kyung,Kim, Youngsoo,Lee, Kiho,Lee, Heesoon
supporting information, p. 2604 - 2608 (2019/08/07)
We have designed and synthesized twenty-six N-arylindazole-3-carboxamide (3a-p) and N-benzoylindazole (6a-j) derivatives to discover with excellent inhibition activities of α-MSH-stimulated melanogenesis. In the bio evaluation studies of these compounds,
