69676-63-7Relevant articles and documents
Hybrid rigid/soft and biologic/synthetic materials: Polymers grafted onto cellulose microcrystals
Harrisson, Simon,Drisko, Glenna L.,Malmstroem, Eva,Hult, Anders,Wooley, Karen L.
, p. 1214 - 1223 (2011)
Rigid nanoscale polymer rods were prepared by grafting preformed amine-terminated poly(styrene) and poly(tert-butyl acrylate) onto oxidized cellulose microcrystals. Low polydispersity polymers, grown using atom transfer radical polymerization, were characterized and purified prior to cellulose attachment. Oxidation of the cellulose microcrystal led to the formation of carboxylic acids on the surface of the microcrystals. Covalent attachment of the polymers onto the cellulose microcrystals was achieved via a carbodiimide-mediated amidation reaction. The length and diameter of the polymer-cellulose composites increased upon surface modification. Typically, polymer-cellulose composites are synthesized by a grafting-from method because it can be difficult to obtain sufficient graft density using a grafting-to preparation. However, the composites reported here comprised 60-64% grafted polymer by mass. This degree of grafting-to allowed the composite to form stable suspensions in organic solvents.
Preparation method of precursor raw material Pht-AEEA-AEEA for somatostatin side chain
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Paragraph 0047-0052; 0083-0088; 0119-0124, (2021/10/05)
The preparation method comprises the following steps: in the reaction kettle, adding AEEA phthalic AEEA anhydride, toluene, opening stirring, heating and refluxing, separating the 100 ml water Pht through a water separator, ending the reaction, and lowering the temperature to room temperature. Post-treatment: addition of saturated NaHCO3 The solution was washed 1h. The method is scientific and reasonable in structure, safe and convenient to use, and safe and convenient to use; the product is prepared by using @timetime@ petroleum ether 1:20, AEEA-AEEA ethyl ester as a raw material, PA-AEEA - ethyl ester preparation third and deamination, and then PA ethyl ester is prepared by using the solid phase method AEEA AEEA . 4th-Pht-AEEA Ethyl AEEA -ethyl ester.
IMIDAZOPYRAZINE DERIVATIVES AS ANTIBACTERIAL AGENTS
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Page/Page column 44; 68-69, (2020/07/14)
The invention provides novel imidazopyrazine derivatives having the general formula (I), wherein A and R1 to R11 are as described herein NA (I) and pharmaceutically acceptable salts thereof.5 Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.
NOVEL IMIDAZOPYRAZINE DERIVATIVES AS ANTIBACTERIALS
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Page/Page column 88; 115, (2020/07/14)
The invention provides novel imidazopyrazine derivatives having general formula (I), wherein R1 to R11 are as described herein, and pharmaceutically acceptable salts thereof. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and related diseases.
IMIDAZOPYRAZINE DERIVATIVES AS ANTIBACTERIAL AGENTS
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Page/Page column 111-112, (2020/07/14)
The invention provides novel imidazopyrazine derivatives having the general formula (I), wherein A and R1 to R11 are as described herein formula (I) and pharmaceutically acceptable salts thereof. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.
NOVEL IMIDAZOPYRAZINE DERIVATIVES
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Page/Page column 81, (2020/07/14)
The invention provides novel imidazopyrazine derivatives having the general formula (I), wherein A and R1 to R11 are as described herein (I) and pharmaceutically acceptable salts thereof. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and related diseases.
IMIDAZOPYRAZINE DERIVATIVES AS ANTIBACTERIALS
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Page/Page column 63, (2020/07/14)
The invention provides novel imidazopyrazine derivatives having the general formula (I), wherein A and R1 to R14 are as described herein (I) and pharmaceutically acceptable salts thereof. Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.
Preparation method of [2-[1-(Fmoc-amino)ethoxy]ethoxy]acetic acid
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Paragraph 0065-0066; 0070, (2019/09/17)
The invention provides a preparation method of [2-[1-(Fmoc-amino)ethoxy]ethoxy]acetic acid. The preparation method comprises steps as follows: amino protection is performed on diglycolamine by use ofphthalic anhydride, an obtained intermediate and halo-acetic acid or halo-acetate are subjected to a reaction, deprotection or deprotection and hydrolysis are performed, a product reacts with a Fmoc-based amino protection reagent, and [2-[1-(Fmoc-amino)ethoxy]ethoxy]acetic acid is obtained. In the preparation method, phthalic anhydride and diglycolamine are taken as initial raw materials, short time is required by an amino protection reaction, an obtained intermediate compound has good stability, can be preserved for a long time and does not react with water, water-soluble impurities (such asthe raw material diglycolamine, a byproduct phthalic acid and the like) can be separated through extraction, so that an amino protection product with high purity is obtained, and the purity and the yield of the target product are also improved.
Curcumin derivative and uses thereof
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Paragraph 0150; 0154; 0155, (2019/08/01)
The present invention relates to a curcumin derivative represented by a general formula (I) or a pharmaceutically acceptable salt thereof, and a preparation method thereof, a composition containing aneffective amount of the compound represented by the general formula (I) or the pharmaceutically acceptable salt thereof, and applications of the compound represented by the general formula (I) or thepharmaceutically acceptable salt thereof in preparation of drugs for treatment of cancers, fatty liver, inflammations and the like, wherein R and R are defined in the specification.
PREPARATION METHOD OF 2-(2-PHTHLIMIDOETHOXY) ACETIC ACID
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Paragraph 0040 - 0044, (2016/10/07)
PURPOSE: A method for preparing 2-(2-phthalimidoethoxy)acetic acid is provided to cheaply obtain 2-(2-phthalimidoethoxy)acetic acid of high purity. CONSTITUTION: A 2-(2-phthalimidoethoxy)acetic acid is prepared by dropping sodium chloride(NaClO_2) solution and sodium hyperchloride(NaOCl) solution to 2-(2-phthalimidoethoxy)ethanol of chemical formula 3 under the presence of 2,2,6,6-tetramethylpiperidine 1-oxyl(TEMPO) catalyst and oxidizing 2-(2-phthalimidoethoxy)ethanol. The 2-(2-phthalimidoethoxy)ethanol is used in an organic solvent of nitrile, ketone, haloalkan, or ester or water and buffer solution. The organic solvent is aceto nitrile, acetone, methyl ethyl ketone, dichlomethane, dichloroethan, or ethyl acetate.