69689-88-9Relevant academic research and scientific papers
Photochemical C–H Activation: Generation of Indole and Carbazole Libraries, and First Total Synthesis of Clausenawalline D
Alimi, Isak,Remy, Richard,Bochet, Christian G.
, p. 3197 - 3210 (2017)
The photolysis of N-aryltriazoles and N-arylbenzotriazoles leads to indoles and carbazoles, respectively. Because libraries of triazoles can be accessed rapidly, for example by the copper-catalyzed [3+2] cycloaddition reaction between alkynes and azides, this reaction allows the preparation of indoles in a single operation, by the simultaneous photolysis of the precursor library. As an example of such a synthesis of carbazoles, we prepared for the first time clausenawalline D, an antimalarial alkaloid that was recently isolated.
Novel synthesis of 1,4,5-trisubstituted 1,2,3-triazoles via a one-pot three-component reaction of boronic acids, azide, and active methylene ketones
Zhang, Jian,Jin, Guanyi,Xiao, Senhan,Wu, Jingjing,Cao, Song
, p. 2352 - 2356 (2013/03/29)
A series of 1-aryl-5-trifluoromethyl (or difluoromethyl)-1,4,5- trisubstituted 1,2,3-triazoles were synthesized in high yield by a novel one-pot three-component reaction of arylboronic acids, sodium azide, and active methylene ketones, such as ethyl 4,4-difluoroacetoacetate or ethyl 4,4,4-trifluoroacetoacetate in the presence of Cu(OAc)2 and piperidine using a DMSO/H2O (10/1) mixture as solvent.
Organocatalytic enamide-azide cycloaddition reactions: Regiospecific synthesis of 1,4,5-trisubstituted-1,2,3-triazoles
Danence, Lee Jin Tu,Gao, Yaojun,Li, Maoguo,Huang, Yuan,Wang, Jian
supporting information; experimental part, p. 3584 - 3587 (2011/05/04)
Heterocycles in one click: A novel organocatalytic enamide-azide cycloaddition reaction has been developed. This synthetic procedure represents a new method for the efficient construction of 1,4,5-trisubstituted-1,2,3- triazoles under mild reaction condit
Addition of diazoacetonitrile to N-benzylidene-anilines. Synthesis and decomposition of 4-cyano-1,5-diaryl,Δ2-1,2,3-triazolines
Roelants,Bruylants
, p. 2229 - 2232 (2007/10/06)
Addition of diazoacetonitrile to para-substituted N-benzilidene-anilines has been studied. The addition is easier if the substituent is an electrodonating group. Products obtained are Δ2-1,2,3-triazolines or aziridnes, and enamines resulting from the decomposition of the triazolines with migration of the 5-aryl substituent. Decomposition of the triazolines under various conditions has also been studied.
