69691-19-6

Upstream product

• 67-56-1 methanol 
• 802294-64-0 propionic acid 
• 3355-28-0 1-Bromo-2-butyne 
• 186581-53-3 diazomethane 
• 51577-97-0 2-methylhex-4-ynoic acid 
• 74-88-4 methyl iodide 

Downstream Products

• 1035094-10-0 (E)-2,2,3,3-d4-5-((3aS,4R,5R,6aS)-5-hydroxy-4-((3S,E)-3-hydroxy-4-methyloct-1-en-6-ynyl)hexahydropentalen-2(1H)-ylidene)pentanoic acid 
• 88430-50-6 (±)-(1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(E)-(3S,4RS)-3-hydroxy-4-methyl-1-octen-6-ynyl]-1H-cyclopenta[b]-benzofuran-5-butanoic acid 

Relevant academic research and scientific papers

PROSTACYCLIN DERIVATIVES

This invention relates to novel prostacyclin derivatives and acceptable salts thereof. The invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions benefic

PROSTACYCLIN DERIVATIVES

This invention relates to novel prostacyclin derivatives, their acceptable acid addition salts, solvates, hydrates and polymorphs thereof. The invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions beneficially treated by prostacyclin, and in particular those diseases and conditions beneficially treated by dilators of systemic and pulmonary arterial vascular beds or by platelet aggregation inhibitors.

Synthesis of 5,6,7-trinor-4,8-inter-m-phenylene PGI2 and Beraprost

We have disclosed a new class of stable PGI2 analogue, 5,6,7-trinor- 4,8-inter-m-phenylene PGI2 which has a phenyl ether moiety instead of enol- ether skeleton in PGI2. The m-phenylene PGI2 and its derivative (Betaprost) were synthesized via dihydrocyclopenta[b]benzofuran derivatives as key intermediates by ortho-selective metal-halogen exchange reaction with Grignard reagents and subsequent copper-catalyzed cyclization. The ω-side chains were introduced by stereoselective epoxide formation or Prins reaction.