697287-57-3

Basic information

• Product Name: [3-(2,3-dimethoxy-phenyl)-isoxazol-5-ylmethyl]-{2-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-ethyl}-amine
• CAS NO: 697287-57-3
• Molecular Weight: 490.525
• Mol File: 697287-57-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [3-(2,3-dimethoxy-phenyl)-isoxazol-5-ylmethyl]-{2-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-ethyl}-amine(CAS DataBase Reference)
• NIST Chemistry Reference: [3-(2,3-dimethoxy-phenyl)-isoxazol-5-ylmethyl]-{2-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-ethyl}-amine(697287-57-3)
• EPA Substance Registry System: [3-(2,3-dimethoxy-phenyl)-isoxazol-5-ylmethyl]-{2-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-ethyl}-amine(697287-57-3)

Safety Data

• Hazardous Substances Data: 697287-57-3(Hazardous Substances Data)

Upstream product

• 15532-75-9 1-(3-Trifluoromethylphenyl)piperazine 
• 27144-85-0 2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethan-1-amine 
• 808740-47-8 3-(2,3-dimethoxy-phenyl)-isoxazole-5-carbaldehyde 
• 86-51-1 2,3-dimethyoxybenzaldehyde 

Relevant articles and documents

Synthesis and biological evaluation of novel T-type Ca2+ channel blockers

A small molecule library of piperazinylalkylisoxazole derivatives containing about 600 compounds was designed, synthesized and evaluated for blocking effects on T-type Ca2+ channel. Several ligands were identified to possess high inhibitory activity against the T-type Ca 2+ channel. The compound 21 with trifluoromethyl substituents at C3-position of phenyl group (R1) and C2- position of phenyl group (R2) showed the highest inhibitory activity with IC50 value of 1.02μM, which is comparable to that of mibefradil.