69729-17-5Relevant academic research and scientific papers
Topical composition for preventing or treating acne vulgaris
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, (2008/06/13)
A topical composition for treating or preventing acne vulgaris which comprises at least one saturated or unsaturated chain alcohol having 18 carbon atoms represented by formula (1): STR1 wherein a dotted line represents either the presence or the absence of a double bond as an active ingredient, makes it possible to inhibit proliferation of Propionibacterium acnes, which causes acne vulgaris, or kill the bacterium to effectively treat or prevent acne vulgaris. The compound represented by formula (1) can be easily synthesized and has an extremely low toxicity. Furthermore, it exerts an excellent antibacterial effect on Propionibacterium acnes even when used at a relatively low concentration. Thus it can be used only in a small amount , which ensures a high safety.
Synthesis of Chiral Alcohol and Ester Pheromones through Enzyme-Catalysed Hydrolysis using Pseudomonas fluorescens Lipase: Preparation of (2R,6S,10S)-6,10,14-Trimethylpentadecan-2-ol and the Propionate of (2R,8R)-8-Methyldecan-2-ol
Naoshima, Yoshinobu,Munakata, Yoshihito,Yoshida, Satoshi,Funai, Akio
, p. 549 - 553 (2007/10/02)
(2R,6S,10S)-6,10,14-Trimethylpentadecan-2-ol , one of the stereoisomers of the sex pheromone of Corcyra cephalonica Stainton, was synthesized in highly optically pure form by the hydrolysis of the 2,2,2-trichloroethyl carbonate of (2RS,6S,
Microbial Oxidation of Isoprenoid Alkanes, Phytane, Norpristane and Farnesane
Nakajima, Kenji,Sato, Akio,Takahara, Yoshimasa,Iida, Takeo
, p. 1993 - 2002 (2007/10/02)
Rhodococcus sp.BPM 1613, a pristane oxidizing microorganism, grows on isoprenoid hydrocarbons such as phytane (2,6,10,14-tetramethylhexadecane), norpristane (2,6,10-trimethyl-pentadecane) and farnesane (2,6,10-trimethyldodecane) as the sole carbon source, resulting in accumulation of oxidation products in the culture broth.The oxidation products of phytane, norpristane and farnesane in the respective culture broth were isolated and purified by the use of silica gel column chromatography.Their chemical structures were determined by instrumental analyses such as IR, NMR and mass spectrometry.The oxidation products of phytane were identified as 2,6,10,14-tetramethyl-1-hexadecanol and 2,6,10,14-tetramethylhexadecanoic acid, the product of norpristane as 2,6,10-trimethyl-1-pentadecanol, and that of farnesane as 2,6,10-trimethyl-1-dodecanol.All these oxidation products were either monoalcohols or monocarboxylic acids derived through oxidation of the isopropyl terminus of each alkane.In addition, the relationship between the terminal structure of isoprenoid hydrocarbons and microbial oxidation was explored on the basis of these results.
