6973-78-0

Usage

InChI:InChI=1/C12H15NO4/c1-3-11(12(14)17-4-2)9-5-7-10(8-6-9)13(15)16/h5-8,11H,3-4H2,1-2H3

Upstream product

• 119-43-7 ethyl 2-phenylbutanoate 
• 7425-45-8 ethyl 2-chlorobutyrate 
• 98-95-3 nitrobenzene 
• 61829-56-9 ethyl α-(phenylthio)butyrate 
• 56149-37-2 24-phenoxybutyric acid ethyl ester 
• 5445-26-1 ETHYL 4-NITROPHENYLACETATE 
• 75-03-6 ethyl iodide 
• 7463-53-8 2RS-(4-nitrophenyl)butanoic acid 
• 64-17-5 ethanol 
• 90-27-7 2-Phenylbutyric acid 
• 533-68-6 2-bromobutyric acid ethyl ester 

Downstream Products

• 57960-84-6 2-(4-Aminophenyl)-buttersaeureethylester 
• 1454311-33-1 17β-acetamide-androst-5-en-7-one-3β-yl 2-[4-N,N-bis(2-chloroethyl)amino-phenyl]butanoate 
• 1085269-41-5 17α-aza-D-homo-androst-5-en-7,17-dione-3β-yl 2-[4-N,N-bis(2-chloroethyl)amino-phenyl]butanoate 
• 1454311-38-6 7α-aza-B-homo-cholest-5-en-7-one-3β-yl 2-[4-N,N-bis(2-chloroethyl)amino-phenyl]butanoate 
• 1454311-42-2 7α-aza-B-homo-androst-5-en-7,17-dione-3β-yl 2-[4-N,N-bis(2-chloroethyl)amino-phenyl]butanoate 
• 1454311-46-6 7α-aza-B-homo-17β-acetamide-androst-5-en-7-one-3β-yl 2-[4-N,N-bis(2-chloroethyl)amino-phenyl]butanoate 
• 1454311-50-2 7α,17α-diaza-B,D-dihomoandrost-5-en-7,17-dione-3β-yl 2-[4-N,N-bis(2-chloroethyl)amino-phenyl]butanoate 
• 1454311-54-6 androst-5-en-17-one-3β-yl 2-[4-N,N-bis(2-chloroethyl)amino-phenyl]butanoate 
• 1454311-58-0 17β-acetamide-androst-5-en-3β-yl 2-[4-N,N-bis(2-chloroethyl)amino-phenyl]butanoate 
• 1454311-63-7 17α-aza-D-homo-androst-5-en-17-one-3β-yl 2-[4-N,N-bis(2-chloroethyl)amino-phenyl]butanoate 
• 1454311-14-8 ethyl 2-[4-N,N-bis(2-hydroxyethyl)aminophenyl]butanoate 
• 1454311-19-3 ethyl 2-[4-N,N-bis(2-chloroethyl)aminophenyl]butanoate 
• 6555-38-0 2-[4-N,N-bis(2-chloroethyl)amino-phenyl]butanoic acid 
• 1454311-23-9 cholest-5-en-7-one-3β-yl 2-[4-N,N-bis(2-chloroethyl)amino-phenyl]butanoate 

Relevant academic research and scientific papers

Steroidal esters of the aromatic nitrogen mustard 2-[4-N,N-bis(2- chloroethyl)amino-phenyl]butanoic acid (2-PHE-BU): Synthesis and in-vivo biological evaluation

On the basis of the results of in-silico predictions and in an effort to extend our structure-activity relationship studies, the aromatic nitrogen mustard 2-[4-N,N-bis(2-chloroethyl) amino-phenyl]butanoic acid (2-PHE-BU) was synthesized and conjugated with various steroidal alcohols. The resulting steroidal esters were evaluated for their in-vivo toxicity and antileukemic activity in P388-leukemia-bearing mice. The new derivatives showed significantly reduced toxicity and marginally improved antileukemic activity compared with free 2-PHE-BU. Nevertheless, they did not prove to be superior either to the template steroidal ester used for in-silico predictions or to previously synthesized steroidal esters of aromatic nitrogen mustards. The results obtained indicate that in-silico design predictions may guide the design and synthesis of new bioactive steroidal esters, but further parameters should be considered aiming at the discovery of compounds with optimum activity.

The synthesis of (±)-aminoglutethimide via vicarious nucleophilic aromatic substitution of hydrogen

The synthesis of aminoglutethimide via a one-pot coupling of nitrobenzene, ethyl 2-chlorobutyrate and 3-bromopropionitrile has been achieved via a process involving sequential vicarious nucleophilic aromatic substitution and alkylation.

Glutamine derivatives

Glutamine derivatives and non-toxic salts thereof have been found to have immunomodulating activities.

Tertiary aminoacids

New α-(cyclic tert. aminophenyl)-aliphatic acids, e.g. those of the formula STR1 and functional derivatives thereof, are anti-inflammatory agents.

Tertiary aminoacids

New α-(cyclic tert. aminophenyl)-aliphatic acids, e.g. those of the formula STR1 AND FUNCTIONAL DERIVATIVES THEREOF, ARE ANTI-INFLAMMATORY AGENTS.