6973-78-0

Basic information

• Product Name: ethyl 2-(4-nitrophenyl)butanoate
• Synonyms: ethyl 2-(4-nitrophenyl)butanoate
• CAS NO: 6973-78-0
• Molecular Formula: C₁₂H₁₅NO₄
• Molecular Weight: 237.25
• Mol File: 6973-78-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 335.5°C at 760 mmHg
• Flash Point: 136.2°C
• Appearance: /
• Density: 1.16g/cm³
• Vapor Pressure: 0.000119mmHg at 25°C
• Refractive Index: 1.525
• CAS DataBase Reference: ethyl 2-(4-nitrophenyl)butanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(4-nitrophenyl)butanoate(6973-78-0)
• EPA Substance Registry System: ethyl 2-(4-nitrophenyl)butanoate(6973-78-0)

Safety Data

• Hazardous Substances Data: 6973-78-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H15NO4/c1-3-11(12(14)17-4-2)9-5-7-10(8-6-9)13(15)16/h5-8,11H,3-4H2,1-2H3

Upstream product

• 7463-53-8 2RS-(4-nitrophenyl)butanoic acid 
• 64-17-5 ethanol 
• 5445-26-1 ETHYL 4-NITROPHENYLACETATE 
• 75-03-6 ethyl iodide 
• 90-27-7 2-Phenylbutyric acid 
• 533-68-6 2-bromobutyric acid ethyl ester 
• 56149-37-2 24-phenoxybutyric acid ethyl ester 
• 98-95-3 nitrobenzene 
• 61829-56-9 ethyl α-(phenylthio)butyrate 
• 7425-45-8 ethyl 2-chlorobutyrate 
• 119-43-7 ethyl 2-phenylbutanoate 

Downstream Products

• 203808-68-8 4-(ethoxycarbonyl)-4-(4'-nitrophenyl)hexanonitrile 
• 1454311-33-1 17β-acetamide-androst-5-en-7-one-3β-yl 2-[4-N,N-bis(2-chloroethyl)amino-phenyl]butanoate 
• 1085269-41-5 17α-aza-D-homo-androst-5-en-7,17-dione-3β-yl 2-[4-N,N-bis(2-chloroethyl)amino-phenyl]butanoate 
• 1454311-38-6 7α-aza-B-homo-cholest-5-en-7-one-3β-yl 2-[4-N,N-bis(2-chloroethyl)amino-phenyl]butanoate 
• 1454311-42-2 7α-aza-B-homo-androst-5-en-7,17-dione-3β-yl 2-[4-N,N-bis(2-chloroethyl)amino-phenyl]butanoate 
• 1454311-46-6 7α-aza-B-homo-17β-acetamide-androst-5-en-7-one-3β-yl 2-[4-N,N-bis(2-chloroethyl)amino-phenyl]butanoate 
• 1454311-50-2 7α,17α-diaza-B,D-dihomoandrost-5-en-7,17-dione-3β-yl 2-[4-N,N-bis(2-chloroethyl)amino-phenyl]butanoate 
• 1454311-54-6 androst-5-en-17-one-3β-yl 2-[4-N,N-bis(2-chloroethyl)amino-phenyl]butanoate 
• 1454311-58-0 17β-acetamide-androst-5-en-3β-yl 2-[4-N,N-bis(2-chloroethyl)amino-phenyl]butanoate 
• 1454311-63-7 17α-aza-D-homo-androst-5-en-17-one-3β-yl 2-[4-N,N-bis(2-chloroethyl)amino-phenyl]butanoate 
• 1454311-14-8 ethyl 2-[4-N,N-bis(2-hydroxyethyl)aminophenyl]butanoate 
• 1454311-19-3 ethyl 2-[4-N,N-bis(2-chloroethyl)aminophenyl]butanoate 
• 6555-38-0 2-[4-N,N-bis(2-chloroethyl)amino-phenyl]butanoic acid 
• 1454311-23-9 cholest-5-en-7-one-3β-yl 2-[4-N,N-bis(2-chloroethyl)amino-phenyl]butanoate 

Relevant articles and documents

Steroidal esters of the aromatic nitrogen mustard 2-[4-N,N-bis(2- chloroethyl)amino-phenyl]butanoic acid (2-PHE-BU): Synthesis and in-vivo biological evaluation

On the basis of the results of in-silico predictions and in an effort to extend our structure-activity relationship studies, the aromatic nitrogen mustard 2-[4-N,N-bis(2-chloroethyl) amino-phenyl]butanoic acid (2-PHE-BU) was synthesized and conjugated with various steroidal alcohols. The resulting steroidal esters were evaluated for their in-vivo toxicity and antileukemic activity in P388-leukemia-bearing mice. The new derivatives showed significantly reduced toxicity and marginally improved antileukemic activity compared with free 2-PHE-BU. Nevertheless, they did not prove to be superior either to the template steroidal ester used for in-silico predictions or to previously synthesized steroidal esters of aromatic nitrogen mustards. The results obtained indicate that in-silico design predictions may guide the design and synthesis of new bioactive steroidal esters, but further parameters should be considered aiming at the discovery of compounds with optimum activity.

Glutamine derivatives

Glutamine derivatives and non-toxic salts thereof have been found to have immunomodulating activities.

Potential antineoplastics. V. Synthesis of N,N-bis(2-chloroethyl)-5-[1-ethyl-2-(4-methoxyphenyl)-2-butenyl]-2-methoxyaniline

-