697305-53-6

Basic information

• Product Name: 2-(4-BOC-PIPERAZINO-1-YL)-5-FLUOROBENZALDEHYDE
• Synonyms: 2-(4-BOC-PIPERAZINO-1-YL)-5-FLUOROBENZALDEHYDE
• CAS NO: 697305-53-6
• Molecular Formula: C₁₆H₂₁FN₂O₃
• Molecular Weight: 308.351
• Mol File: 697305-53-6.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(4-BOC-PIPERAZINO-1-YL)-5-FLUOROBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-BOC-PIPERAZINO-1-YL)-5-FLUOROBENZALDEHYDE(697305-53-6)
• EPA Substance Registry System: 2-(4-BOC-PIPERAZINO-1-YL)-5-FLUOROBENZALDEHYDE(697305-53-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 697305-53-6(Hazardous Substances Data)

Usage

General Description

2-(4-BOC-PIPERAZINO-1-YL)-5-FLUOROBENZALDEHYDE is a chemical compound that is commonly used in medicinal chemistry and pharmaceutical research. It consists of a 5-fluorobenzaldehyde group attached to a piperazine ring with a tert-butoxycarbonyl (BOC) protecting group. The piperazine ring makes it a potential candidate for drug development due to its ability to interact with biological targets. The 5-fluorobenzaldehyde group also provides a useful synthetic handle for further modifications and can be used as a precursor for various pharmaceutical compounds. Overall, 2-(4-BOC-PIPERAZINO-1-YL)-5-FLUOROBENZALDEHYDE is a valuable intermediate in the synthesis of potential drug candidates and has applications in medicinal and synthetic chemistry.

Upstream product

• 697305-52-5 tert-butyl 4-(2-bromo-4-fluorophenyl)piperazine-1-carboxylate 
• 68-12-2 N,N-dimethyl-formamide 
• 1197193-39-7 5-fluoro-2-(piperazin-1-yl)benzoic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1253383-98-0 2-{4-[(tert-butoxy)carbonyl]piperazin-1-yl}-5-fluorobenzoic acid 
• 2646-90-4 2,5-difluorobenzaldehyde 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 

Downstream Products

• 869478-20-6 4-{4-fluoro-2-[((S_S)-2-methyl-propane-2-sulfinylimino)-methyl]-phenyl}-piperazine-1-carboxylic acid tert-butyl ester 
• 869478-21-7 4-{4-fluoro-2-[((R_S)-2-methyl-propane-2-sulfinylimino)-methyl]-phenyl}-piperazine-1-carboxylic acid tert-butyl ester 
• 910299-91-1 1-{4-[2-(1-amino-2-benzyloxy-ethyl)-4-fluoro-phenyl]-piperazin-1-yl}-3-(2,4-dichloro-phenyl)-propan-1-one 
• 910300-26-4 4-{2-[2-benzyloxy-1-(2-methyl-propane-2-sulfinylamino)-ethyl]-4-fluoro-phenyl}-piperazine-1-carboxylic acid tert-butyl ester 
• 910299-90-0 1-{4-[2-(1-amino-2-ethoxy-ethyl)-4-fluoro-phenyl]-piperazin-1-yl}-3-(2,4-dichloro-phenyl)-propan-1-one 
• 910300-25-3 4-{2-[2-ethoxy-1-(2-methyl-propane-2-sulfinylamino)-ethyl]-4-fluoro-phenyl}-piperazine-1-carboxylic acid tert-butyl ester 
• 910300-32-2 2-methyl-propane-2-sulfinic acid [2-benzyloxy-1-(5-fluoro-2-piperazin-1-yl-phenyl)-ethyl]-amide 
• 910300-35-5 2-Methyl-propane-2-sulfinic acid [(S)-1-(5-fluoro-2-piperazin-1-yl-phenyl)-3-methyl-butyl]-amide 
• 910300-31-1 2-methyl-propane-2-sulfinic acid [2-ethoxy-1-(5-fluoro-2-piperazin-1-yl-phenyl)-ethyl]-amide 

Relevant articles and documents

3-(5-METHOXY-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND USES THEREOF

The present disclosure relates to compounds of formula (I') and pharmaceutical compositions and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders (e.g., hemoglobinopathies, e.g., beta-hemoglobinopathies), such as sickle cell disease and beta-thalassemia.

Practical asymmetric synthesis of α-branched 2- piperazinylbenzylamines by 1,2-additions of organometallic reagents to N-tert-butanesulfinyl imines

2-[4-(tert-Butoxycarbonyl)piperazinyl] benzylidene-tert-butanesulfinamides underwent nucleophilic 1,2-addition with different organometallic reagents to give highly diastereomerically enriched adducts. X-ray crystallography of the resulting α-branched N-B