697305-53-6

Usage

Uses

Used in Medicinal Chemistry:
2-(4-BOC-PIPERAZINO-1-YL)-5-FLUOROBENZALDEHYDE is used as a valuable intermediate for the synthesis of potential drug candidates due to its ability to interact with biological targets.
Used in Pharmaceutical Research:
2-(4-BOC-PIPERAZINO-1-YL)-5-FLUOROBENZALDEHYDE is used as a precursor for various pharmaceutical compounds, providing a useful synthetic handle for further modifications.

Upstream product

• 697305-52-5 tert-butyl 4-(2-bromo-4-fluorophenyl)piperazine-1-carboxylate 
• 68-12-2 N,N-dimethyl-formamide 
• 1197193-39-7 5-fluoro-2-(piperazin-1-yl)benzoic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1253383-98-0 2-{4-[(tert-butoxy)carbonyl]piperazin-1-yl}-5-fluorobenzoic acid 
• 2646-90-4 2,5-difluorobenzaldehyde 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 

Downstream Products

• 910299-91-1 1-{4-[2-(1-amino-2-benzyloxy-ethyl)-4-fluoro-phenyl]-piperazin-1-yl}-3-(2,4-dichloro-phenyl)-propan-1-one 
• 910300-26-4 4-{2-[2-benzyloxy-1-(2-methyl-propane-2-sulfinylamino)-ethyl]-4-fluoro-phenyl}-piperazine-1-carboxylic acid tert-butyl ester 
• 910299-90-0 1-{4-[2-(1-amino-2-ethoxy-ethyl)-4-fluoro-phenyl]-piperazin-1-yl}-3-(2,4-dichloro-phenyl)-propan-1-one 
• 910300-25-3 4-{2-[2-ethoxy-1-(2-methyl-propane-2-sulfinylamino)-ethyl]-4-fluoro-phenyl}-piperazine-1-carboxylic acid tert-butyl ester 
• 910300-32-2 2-methyl-propane-2-sulfinic acid [2-benzyloxy-1-(5-fluoro-2-piperazin-1-yl-phenyl)-ethyl]-amide 
• 910300-35-5 2-Methyl-propane-2-sulfinic acid [(S)-1-(5-fluoro-2-piperazin-1-yl-phenyl)-3-methyl-butyl]-amide 
• 910300-31-1 2-methyl-propane-2-sulfinic acid [2-ethoxy-1-(5-fluoro-2-piperazin-1-yl-phenyl)-ethyl]-amide 
• 869478-20-6 4-{4-fluoro-2-[((S_S)-2-methyl-propane-2-sulfinylimino)-methyl]-phenyl}-piperazine-1-carboxylic acid tert-butyl ester 
• 869478-21-7 4-{4-fluoro-2-[((R_S)-2-methyl-propane-2-sulfinylimino)-methyl]-phenyl}-piperazine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

3-(5-METHOXY-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND USES THEREOF

The present disclosure relates to compounds of formula (I') and pharmaceutical compositions and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders (e.g., hemoglobinopathies, e.g., beta-hemoglobinopathies), such as sickle cell disease and beta-thalassemia.

Arylpropionylpiperazines as antagonists of the human melanocortin-4 receptor

A series of 3-arylpropionylpiperazines were synthesized as antagonists of the melanocortin-4 receptor. Their potency was found to be increased by replacing the α-methyl substituent of the initial lead 11 with a larger s-Bu or i-Bu group. Further potency enhancement was observed when a glycine or β-alanine was incorporated onto the benzylamine. Some compounds demonstrated good potency, moderate selectivity, and oral bioavailability.

Practical asymmetric synthesis of α-branched 2- piperazinylbenzylamines by 1,2-additions of organometallic reagents to N-tert-butanesulfinyl imines

2-[4-(tert-Butoxycarbonyl)piperazinyl] benzylidene-tert-butanesulfinamides underwent nucleophilic 1,2-addition with different organometallic reagents to give highly diastereomerically enriched adducts. X-ray crystallography of the resulting α-branched N-B

AMINE COMPOUNDS

The present invention provide a compound of the formula:wherein ring A represents an aromatic ring optionally having substituents; B, Y and Ya are the same or different and each represents a bond, etc.; R1 and R2 are the same or different and each represents a hydrogen atom, etc.; R3 represents a hydrogen atom, etc.; R4 and R5 are the same or different and each represents a hydrogen, etc.; R6 represents an indolyl group optionally having substituents; and Z and Za are the same or different and each represents a hydrogen atom, etc.; or a salt thereof or a prodrug thereof, having a somatostatin receptor binding inhibition activity and is useful for preventing and/or treating diseases associated with somatostatin.