69736-37-4

Upstream product

• 85620-54-8 4-Chloro-3-methyl-hex-1-yn-3-ol 
• 24446-60-4 3-Ethyl-2-ethynyl-2-methyl-oxirane 
• 24446-60-4 3-Ethyl-2-ethynyl-2-methyl-oxirane 
• 13280-00-7 3-chloropentan-2-one 
• 947380-89-4 (4S,5R)-4-(2,2-dibromovinyl)-5-ethyl-2,2,4-trimethyl-1,3-dioxolane 
• 1617-40-9 ethyl (E)-2-methyl-2-pentenoate 
• 159170-70-4 (2S,3R)-1,2-epoxy-2-methylpentan-3-ol 
• 108510-19-6 4,5-dideoxy-2C-methyl-D-erythro-pentitol 
• 96481-55-9 2-methylpent-1-en-3-ol 
• 16958-19-3 (2E)-2-methyl-2-penten-1-ol 
• 85620-56-0 4-Chloro-3-methyl-1-trimethylsilanyl-hex-1-yn-3-ol 
• 85620-56-0 4-Chloro-3-methyl-1-trimethylsilanyl-hex-1-yn-3-ol 
• 67-64-1 acetone 
• 72128-98-4 3-Methyl-hex-1-yne-3,4-diol 

Relevant academic research and scientific papers

Total synthesis of (-)-4,8,10-tridesmethyl telithromycin

Novel sources of antibiotics are required to address the serious problem of antibiotic resistance. Telithromycin (2) is a third-generation macrolide antibiotic prepared from erythromycin (1) and used clinically since 2004. Herein we report the details of

Stereoselective formal total synthesis of (+)-methynolide

(Chemical Equation Presented) A highly stereoselective and convergent formal total synthesis of (+)-methynolide is described. The salient features of this synthesis have been the construction of the C1-C7 and C8-C11fragments via a desymmetrization approach, Sharpless asymmetric epoxidation of an allyl alcohol, respectively, and linkage of both the fragments by Nozaki-Hiyama-Kishi reaction.

STEREO-SELECTIVE SYNTHESIS OF ERYTHRO-3-METHYL-1-HEXYN-3,4-DIOL

A very short stereo-selective preparation of the title compound, an intermediate of methynolide synthesis, is described.