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Usage

Uses

Used in Pharmaceutical Industry:
5-Chloro-2-tetralone is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure allows it to be a key component in the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 5-Chloro-2-tetralone serves as an intermediate in the production of agrochemicals. Its role in this industry is crucial for the synthesis of compounds that can be used in pest control and crop protection, thereby supporting agricultural productivity.
Used in Dye and Pigment Production:
5-Chloro-2-tetralone is utilized in the manufacturing process of dyes and pigments. Its chemical properties make it suitable for creating a range of colorants used in various applications, including textiles, plastics, and printing inks.
Used in Organic Compound Synthesis:
Beyond its applications in specific industries, 5-Chloro-2-tetralone is a versatile building block in the synthesis of other organic compounds. Its reactivity and structural features make it a valuable precursor in organic chemistry for creating a diverse array of molecules with potential applications in various fields.

InChI:InChI=1/C10H9ClO/c11-10-3-1-2-7-6-8(12)4-5-9(7)10/h1-3H,4-6H2

Upstream product

• 74-85-1 ethene 
• 41904-39-6 3-chloro-benzeneacetyl chloride 

Downstream Products

• 620171-72-4 1-benzyl-5-chloro-3,4-dihydro-1H-naphthalen-2-one 

Relevant academic research and scientific papers

Heteroaryl β-tetralin ureas as novel antagonists of human TRPV1

We report on a series of α-substituted-β-tetralin-derived and related phenethyl-based isoquinolinyl and hydroxynaphthyl ureas as potent antagonists of the human TRPV1 receptor. The synthesis and Structure-activity relationships (SAR) of the series are described.

The synthesis of novel cis-α-substituted-β-aminotetralins

Teteralones were converted, in 1 to 3 steps, to α-substituted tetralones. Subsequent reductive amination with ammonium acetate/sodium cyanoborohydride gave the corresponding α-substituted-β-aminotetralins, on a multigram scale, with minimal chromatography for the entire transformation.

5-, 6-, 7- and 8-amino-2-(N,N-di-n-propylamino)-1,2,3,4-tetrahydrophthalenes: Centrally acting DA and 5-HT(1A) agonists

5-, 6-, 7- and 8-Amino-2-(N,N-di-n-propylamino)-1,2,3,4-tetrahydronaphthalene were synthesized and compared with the corresponding phenolic compounds in vivo and in vitro for their effects on central serotonergic (5-HT(1A)) and dopaminergic (D2) systems. The 5- and 8-amino isomers surprisingly showed a 100-fold lower affinity for D2 and 5-HT(1A) receptors, respectively, than their corresponding phenols. This was also reflected in vivo. The 6-amino- and hydroxy-isomers were equipotent, while the 7-amino compound showed in vivo effects both on dopaminergic and serotonergic systems, the latter not being noticed in vitro. Intermediates 8-bromo-2-(N,N-di-n-propylamino)-1,2,3,4-tetrahydronaphthalene and 2-(N,N-di-n-propylamino)-1,2,3,4-tetrahydronaphthalene-8-carboxylic acid methyl ester were also tested and found to be quite potent 5-HT(1A) agonists.