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Usage

Uses

Used in Chemical Synthesis:
(4-methylphenyl)(phenyl)acetonitrile is used as a building block in the synthesis of complex organic compounds. Its unique structure allows for the creation of a wide range of molecules with diverse applications.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, (4-methylphenyl)(phenyl)acetonitrile serves as a precursor for the production of various pharmaceuticals. Its ability to be modified and incorporated into different molecular structures makes it a valuable asset in drug development.
Used in Dye Production:
(4-methylphenyl)(phenyl)acetonitrile is used as a precursor in the production of dyes. Its chemical properties contribute to the color and stability of the dyes, making it an important component in this application.
Used in Agrochemicals:
(4-methylphenyl)(phenyl)acetonitrile is also utilized in the production of agrochemicals, where it can be used to create pesticides, herbicides, and other agricultural products that are essential for maintaining crop health and productivity.
Used in Materials Science:
(4-methylphenyl)(phenyl)acetonitrile may have potential applications in the field of materials science, where its unique properties could be harnessed to develop new materials with specific characteristics.
Used as a Reagent in Organic Reactions:
Furthermore, (4-methylphenyl)(phenyl)acetonitrile can be used as a reagent in various organic reactions, facilitating the synthesis of target compounds and contributing to the advancement of organic chemistry.

Upstream product

• 532-28-5 (RS)-mandelonitrile 
• 108-88-3 toluene 
• 134-84-9 4-Methylbenzophenone 
• 2947-61-7 (4-methylphenyl)acetonitrile 
• 108-86-1 bromobenzene 
• 1882-47-9 2-phenyl-2-(4-methylphenyl)-1-nitroethane 
• 7677-24-9 trimethylsilyl cyanide 
• 1517-63-1 4-methylphenyl(phenyl)methanol 
• 592-04-1 mercury(II) cyanide 
• 5798-79-8 bromo-phenyl-acetonitrile 
• 140-29-4 phenylacetonitrile 
• 25124-94-1 phenyl-p-tolyl-acetic acid amide 

Downstream Products

• 6582-13-4 2-phenyl-2-p-tolyl-ethylamine 
• 134-84-9 4-Methylbenzophenone 
• 120264-81-5 (4-methoxyphenyl)(4-methylphenyl)phenylacetonitrile 
• 24051-20-5 4-bromo-2-phenyl-2-p-tolylbutyronitrile 
• 882979-04-6 4-methylpiperazine-1-carbodithioic acid 3-cyano-3-phenyl-3-(4-methylphenyl)propyl ester 
• 69218-78-6 2,3-Diphenyl-2,3-di-p-tolyl-succinonitrile 
• 109939-99-3 diethyl-(2-phenyl-2-p-tolyl-ethyl)-amine 

Relevant academic research and scientific papers

I2/Li2CO3-promoted cyanation of diarylalcohols through a dual activation process

One-step base promoted strategy for cyanation of α,α-diaryl alcohols has been developed under mild and transition metal-free conditions. This method provides a straightforward and facile way towards the synthesis of β,γ-unsaturated nitriles and α-phenylnitiriles from α-vinyl carbinols and α,α-diaryl methanols, respectively, up to 99% yield. Moreover, various azides and ethers could also be accessed from their respective nucleophiles under standard reaction conditions.

The Concise Synthesis of Unsymmetric Triarylacetonitriles via Pd-Catalyzed Sequential Arylation: A New Synthetic Approach to Tri- and Tetraarylmethanes

The selective synthesis of multiarylated acetonitriles via sequential palladium-catalyzed arylations of chloroacetonitrile is reported. The three aryl groups are installed via a Pd-catalyzed Suzuki-Miyaura cross coupling reaction followed by back-to-back C-H arylations to afford triarylacetonitriles in three steps with no over-arylation at any step. The triarylacetonitrile products can be converted into highly functionalized species including tetraarylmethanes. This new strategy provides rapid access to a variety of unsymmetrical tri- and tetraarylmethane derivatives from simple, readily available starting materials. (Chemical Presented)

Direct transformation of primary nitro compounds into nitriles with sodium-dithionite

A new and practical direct transformation of primary nitro compounds into nitriles with sodium dithionite is described. The reaction is simple, convenient and eliminates the use of expensive and moisture-sensitive reagents. Georg Thieme Verlag Stuttgart New York.

Zn(OTf)2 - Catalyzed direct cyanation of benzylic alcohols - A novel synthesis of α-aryl nitriles

This work demonstrates an efficient method to prepare α-aryl nitriles by direct cyanation of benzylic alcohol with TMSCN in the presence of a catalytic amount of Zn(OTf)2 under heating condition. A variety of benzylic alcohols can be converted into the corresponding α-aryl nitriles in good to excellent yields. 2012 Elsevier Ltd. All rights reserved.

Synthesis and structure-activity relationships of A novel class of dithiocarbamic acid esters as anticancer agent

Based on a novel lead compound 4-methylpiperazine-1-carbodithioic acid 3-cyano-3,3-diphenylpropyl ester 1, the systematic structural modification was carried out. All the synthesized compounds were evaluated for their in-vitro anticancer activities on four to six different cell lines at three different concentrations. Most of the tested compounds could selectively inhibit the growth of HL-60 and Bel-7402 cell lines at a medium concentration. Four compounds (3f, 3g, 3n, and 5) were selected for the IC50 test, and the results revealed that three compounds (3g, 3n, and 5) showed almost the same or a slightly weaker activity than compound 1 against HL-60, and three compounds (3f, 3g, and 3n) showed >2-fold higher potency than compound 1 against Bel-7402. The in-vivo efficacy of 3n · HCl was evaluated with transplanted hepatocyte carcinoma 22 as an in-vivo test model. It was found that 3n · HCl could inhibit significantly the growth of tumor, and that this effect was dose-dependent. Meanwhile, the compound 3n · HCl showed low toxicity compared with compound 1 · HCl as evidenced by the little body-weight loss. These results confirmed that compound 3n · HCl is more potent than the lead compound 1 · HCl. Preliminary structure-activity relationships indicated that: a) Both nitrile group and the cyclic amine containing at least two nitrogens were indispensable moieties to keep the activity; b) substitution of the piperazine ring is unfavorable for the improvement of activity; c) the suitable linker joining the piperazinyl dithiocarboxyl and diphenylacetonitril group should be ethylene; d) a non-coplanar arrangement of the two benzene rings appears to be essential for activity. Based on a novel lead compound 4-methyl-piperazine-1-carbodithioic acid 3-cyano-3,3-diphenyl-propyl ester 1, the systematic structural modification was carried out. Compounds 3g and 3n were found to show more potent biological activities than lead compound 1. Some useful SARs were revealed Copyright

Phenyl-substituted normethadones: Synthesis and pharmacology

Phenyl-substituted normethadone derivatives were synthesized and their affinity (IC50) for opioid receptors was determined by displacement of the specific binding sites of [3H]sufentanyl on rat brain preparations. Substitution resulted in a decrease of affinity in-vitro. These results suggest that normethadone-like compounds may interact with the P subsite of the μ-opioid receptor and that the P subsite has a well-defined cavity shape of stringent dimensions.