69741-69-1

Usage

Uses

Used in Pharmaceutical Research:
Benzeneacetamide, 4-chloro-a-(1-methylethyl)is employed as a reagent in pharmaceutical research for its potential to contribute to the development of new drugs. Its analgesic and antipyretic properties make it a valuable compound for exploring its efficacy in treating pain and fever, respectively.
Used in Organic Synthesis:
In the field of organic synthesis, Benzeneacetamide, 4-chloro-a-(1-methylethyl)serves as a key intermediate for the synthesis of various organic compounds. Its unique structure, which includes a chlorine atom and an isopropyl group, allows for a range of chemical reactions that can lead to the formation of diverse molecules with different applications.

Upstream product

• 2012-81-9 3-Methyl-2-(4'-chlorophenyl)-butyronitrile 
• 2012-74-0 2-(4-chlorophenyl)-3-methylbutyric acid 
• 79-37-8 oxalyl dichloride 

Downstream Products

• 916074-16-3 2-(4-chloro-phenyl)-3-methyl-butyryl isocyanate 
• 55332-38-2 S-isopropyl-4-chlorophenylacetic acid 

Relevant academic research and scientific papers

A novel class of potent influenza virus inhibitors: Polysubstituted acylthiourea and its fused heterocycle derivatives

A series of polysubstituted and fused heterocycle derivatives of acylthiourea was prepared and the biological activity against influenza virus was evaluated. Of the analogues that demonstrated IC50s 0.1 μM, acylthiourea derivatives 16 and 50 were further investigated as candidates with the most potential for future development. The SAR of these compounds are discussed and they represent a novel class of highly potent and selective inhibitors of influenza virus.

Synthesis and evaluation of a new series of substituted acyl(thio)urea and thiadiazolo [2,3-a] pyrimidine derivatives as potent inhibitors of influenza virus neuraminidase

A series of substituted acyl(thio)urea and 2H-1,2,4-thiadiazolo [2,3-a] pyrimidine derivatives were prepared and both of their cell culture and enzymatic activity toward influenza virus were tested. Their in vitro neuraminidase inhibitory activities were in good agreement with the corresponding activities in cultured cells and they were evaluated as potent neuraminidase inhibitors. Of the analogues that demonstrated IC50s 0.1 μM, 16 and 60 were further investigated as candidates with the most potential for future development. The molecular docking work of the representative compound was described to provide more insight into their mechanism of action and further rationalize the observations of this new series herein, which represents a novel class of highly potent and selective inhibitors of influenza virus.

Enantioselective Hydrolysis of (RS)-2-isopropyl-4'-chlorophenylacetonitrile by Pseudomonas sp. B21C9

Pseudomonal sp.B21C9, a new nitrile-degrading microorganism, was isolated from a soil sample.By a hydrolysis of (RS)-isopropyl-4'-chlorophenylacetonitrile using cells of B21C9, (S)-2-isopropyl-4'-chlorophenylacetic acid having excellent optically purity could be obtained.It appeared that the microbial hydrolysis proceeded via stepwise reactions by a nitrile hydratase having poor (S)-selectivity and an amidase having strict (S)-selectivity.

(6-Phenoxy-2-pyridyl) methyl esters of imidates

Novel imidates, intermediates therefor, synthesis thereof and the use of said imidates for the control of pests.