69750-01-2

Usage

Uses

Used in Research Applications:
2-Chloro-6-phenylnicotinic acid is used as a research compound for studying its chemical properties and potential applications in various fields. Its role as a bacterial metabolite makes it a subject of interest for microbiological and biochemical research.
Used in Synthesis Processes:
In the laboratory, 2-Chloro-6-phenylnicotinic acid is used as an intermediate or a building block in the synthesis of more complex molecules. Its unique structure, including the phenyl ring and the chlorine atom, allows for further chemical reactions and modifications, making it a valuable component in the synthesis of new compounds.

InChI:InChI=1/C12H8ClNO2/c13-11-9(12(15)16)6-7-10(14-11)8-4-2-1-3-5-8/h1-7H,(H,15,16)

Upstream product

• 43083-13-2 3-cyano-2-hydroxy-6-phenylpyridine 
• 38496-18-3 2,6-dichloropyridine-3-carboxylic acid 
• 98-80-6 phenylboronic acid 
• 43083-14-3 2-chloro-3-cyano-6-phenylpyridine 

Downstream Products

• 29051-44-3 6-phenylpyridine-3-carboxylic acid 
• 85815-19-6 2-Chloro-6-phenyl-N-(1H-tetrazol-5-yl)-nicotinamide 
• 181823-88-1 2-(2,4-Dimethoxy-benzylsulfanyl)-6-phenyl-nicotinic acid 
• 275384-67-3 2-chloro-6-phenylpyridine-3-carboxylic acid methyl ester 
• 85815-03-8 2-methoxy-6-phenylpyridine-3-carboxylic acid 
• 1202163-75-4 2-methoxy-6-phenylnicotinaldehyde 
• 139326-10-6 3-Amino-6-phenyl-thieno<2,3-b>pyridin-2-carbonitril 
• 92126-72-2 6-phenyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile 
• 69750-00-1 2-chloro-6-phenyl-nicotinamide 
• 1026530-91-5 2-(2,4-Dimethoxy-benzylsulfanyl)-6-phenyl-N-pyridin-4-yl-nicotinamide 
• 1026333-99-2 2-(2,4-Dimethoxy-benzylsulfanyl)-6-phenyl-nicotinoyl chloride 

Relevant academic research and scientific papers

ENZYME INHIBITORS

The present invention provides compounds of formula (I) compositions comprising such compounds; the use of such compounds in therapy; and methods of treating patients with such compounds; wherein A, B, and, n, are as defined herein.

PYRIDINE DERIVATIVES AND APPLICATION OF ANTI-MACOBACTERIUM THEREOF

The present invention provides a series of pyridine derivatives and their preparation method and application thereof. The series of pyridine derivatives can be applied to treating mycobacterium-related diseases, especially to treatments of fatal mycobacterium-related diseases. The fatal diseases may be related to mycobacterium tuberculosis, mycobacterium bovis, mycobacterium avium, and mycobacterium marinum.

PYRIDO [3',2' :4,5] THIENO [3, 2-D] PYRIMIDIN- 4 - YLAMINE DERIVATIVES AND THEIR THERAPEUTICAL USE

The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain fused triaryl amine compounds of the following formula (for convenience, collectively referred to herein as "FTA compounds"), which, inter alia, inhibit LIM kinase (LIMK) activity. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit LIMK activity, and in the treatment of diseases and conditions that are mediated by LIMK, that are ameliorated by the inhibition of LIMK activity, etc., including proliferative conditions such as cancer (e.g., breast cancer, prostate cancer, melanoma, glioma, etc.), as well as vasodilation (including, e.g., hypertension, angina, cerebral vasospasm, and ischemia following subarachnoid hemorrhage), neurodegenerative disorders, atherosclerosis, fibrosis, and inflammatory diseases (including, e.g., Crohn's disease and chronic obstructive pulmonary disease (COPD)), and glaucoma (also known as ocular hypertension).

Efficient synthesis of 6-aryl-2-chloronicotinic acids via Pd catalyzed regioselective suzuki coupling of 2,6-dichloronicotinic acid

(Chemical Equation Presented) A regioselective Suzuki coupling of 2,6-dichloronicotinic acid with aryl boronic acids to synthesize 6-aryl-2-chloronicotinic acids is described. Regioselectivity was achieved in aqueous dioxane using the routinely used catalyst Pd(PPh3) 4.