43083-14-3

Usage

Uses

Used in Pharmaceutical Industry:
2-Chloro-6-phenylnicotinonitrile is used as a synthetic intermediate for the production of various pharmaceuticals. Its ability to be incorporated into the molecular structures of bioactive compounds makes it a valuable component in the development of new drugs with antiviral, antifungal, and antimicrobial properties.
Used in Agrochemical Industry:
In the agrochemical industry, 2-Chloro-6-phenylnicotinonitrile is employed as a key intermediate in the synthesis of agrochemicals. Its involvement in the creation of bioactive molecules contributes to the development of effective solutions for crop protection and pest control.
Used in Specialty Chemicals Production:
2-Chloro-6-phenylnicotinonitrile is used as a building block in the synthesis of specialty chemicals. Its versatility in chemical reactions allows for the creation of unique compounds with specific properties, catering to various industrial needs.
Used in Medicinal Chemistry Research:
As a synthetic intermediate, 2-Chloro-6-phenylnicotinonitrile is utilized in medicinal chemistry research to explore its potential in the development of new therapeutic agents. Its ability to be incorporated into various molecular structures makes it a promising candidate for the discovery of novel drugs with improved efficacy and selectivity.
Used in Material Science:
2-Chloro-6-phenylnicotinonitrile has potential applications in material science, where it can be used to develop new materials with specific properties. Its involvement in the synthesis of various compounds allows for the exploration of its potential in creating innovative materials for diverse applications.
It is important to handle 2-Chloro-6-phenylnicotinonitrile with caution, as it may pose certain health and environmental hazards. Proper safety measures should be taken during its production, use, and disposal to minimize any potential risks.

InChI:InChI=1/C12H7ClN2/c13-12-11(8-14)10(6-7-15-12)9-4-2-1-3-5-9/h1-7H

Upstream product

• 43083-13-2 3-cyano-2-hydroxy-6-phenylpyridine 
• 43083-13-2 1,2-dihydro-2-oxo-6-phenylpyridine-3-carbonitrile 
• 68-12-2 N,N-dimethyl-formamide 
• 98-86-2 acetophenone 
• 109-77-3 malononitrile 
• 98-80-6 phenylboronic acid 
• 38496-18-3 2,6-dichloropyridine-3-carboxylic acid 
• 69750-00-1 2-chloro-6-phenyl-nicotinamide 
• 108-86-1 bromobenzene 
• 24388-23-6 2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole 
• 40381-90-6 2,6-dichloro-3-pyridinecarbonitrile 

Downstream Products

• 69750-01-2 2-chloro-6-phenylpyridine-3-carboxylic acid 
• 1013647-71-6 2-(2-chlorophenoxy)-6-phenylnicotinonitrile 
• 92126-72-2 6-phenyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile 
• 139326-10-6 3-Amino-6-phenyl-thieno<2,3-b>pyridin-2-carbonitril 
• 296797-34-7 methyl 3-amino-6-phenylthieno[2,3-b]pyridine-2-carboxylate 
• 1235487-56-5 C₁₇H₁₇N₃ 

Relevant academic research and scientific papers

Discovery and optimization of thienopyridine derivatives as novel urea transporter inhibitors

Urea transporters (UTs) play an important role in the urine concentrating mechanism and are recognized as novel targets for developing small molecule inhibitors with salt-sparing diuretic activity. Thienoquinoline derivatives, a class of novel UT-B inhibitors identified by our group, play a significant diuresis in animal model. However, the poor solubility and low bioavailability limited its further development. To overcome these shortcomings, the structure modification of thienoquinoline was carried out in this study, which led to the discovery of novel thienopyridine derivatives as specific urea transporter inhibitors. Further optimization obtained the promising preclinical candidate 8n with not only excellent inhibition effect on urea transporters and diuretic activity on rat model, but also suitable water solubility and Log P value.

Pyrazolo [3,4 - the b] pyridine and [...] composition preparation method and use of (by machine translation)

The present invention provides a pyrazolo [3,4 - the b] pyridine and [...] compound of preparation and use, in particular, the present invention provides a following formula (I) compounds are shown, wherein the definition of each group as described in the specification. The compounds of the invention has excellent tyrosine kinase inhibiting activity, so can be used for preparing a series of treating diseases associated with the tyrosine kinase activity of the drug. (by machine translation)

PYRIDO [3',2' :4,5] THIENO [3, 2-D] PYRIMIDIN- 4 - YLAMINE DERIVATIVES AND THEIR THERAPEUTICAL USE

The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain fused triaryl amine compounds of the following formula (for convenience, collectively referred to herein as "FTA compounds"), which, inter alia, inhibit LIM kinase (LIMK) activity. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit LIMK activity, and in the treatment of diseases and conditions that are mediated by LIMK, that are ameliorated by the inhibition of LIMK activity, etc., including proliferative conditions such as cancer (e.g., breast cancer, prostate cancer, melanoma, glioma, etc.), as well as vasodilation (including, e.g., hypertension, angina, cerebral vasospasm, and ischemia following subarachnoid hemorrhage), neurodegenerative disorders, atherosclerosis, fibrosis, and inflammatory diseases (including, e.g., Crohn's disease and chronic obstructive pulmonary disease (COPD)), and glaucoma (also known as ocular hypertension).

A facile method for the synthesis of nicotinonitriles from ketones via a one-pot chloromethyleneiminium salt mediated three-component reaction

Simple enolizable ketones such as acetophenones and benzalacetones were treated with malononitrile under Vilsmeier-Haack reaction conditions to afford 2-chloronicotinonitriles. The reaction proceeds via a one-pot chloromethyleneiminium salt mediated three

2-Chloro-3-cyano-6-phenylpyridine

The molecular structure of the title compound (2-chloro-6-phenylpyridine-3-carbonitrile, C12H7ClN2) is presented. The molecule is nearly planar. Despite strong substituent interactions, the aromaticity of the pyridine frag