43083-13-2

Usage

Uses

Used in Pharmaceutical Research:
2-Oxo-6-Phenyl-1,2-Dihydro-3-Pyridinecarbonitrile is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its structural features make it a candidate for the development of new drugs, particularly in the area of medicinal chemistry.
Used in Chemical Research:
In the field of chemical research, 2-Oxo-6-Phenyl-1,2-Dihydro-3-Pyridinecarbonitrile serves as a subject for studying the properties and reactions of phenylpyridine derivatives. This can contribute to a deeper understanding of the reactivity and potential applications of similar compounds.

InChI:InChI=1/C12H8N2O/c13-8-10-6-7-11(14-12(10)15)9-4-2-1-3-5-9/h1-7H,(H,14,15)

Upstream product

• 41125-10-4 benzoylacetaldehyde sodium salt 
• 98-86-2 acetophenone 
• 107-91-5 cyanoacetic acid amide 
• 109-94-4 formic acid ethyl ester 
• 121017-84-3 5-cyano-6-oxo-2-phenyl-1,6-dihydropyridine-3-carboxylic acid 
• 42731-38-4 (2Z)-3-hydroxy-1-phenyl-2-propen-1-one sodium salt 
• 1201-93-0 1-phenyl-3-dimethylaminoprop-2-enone 
• 54818-68-7 2-cyano-5-dimethylamino-5-phenylpenta-2,4-dienoic acid amide 
• 121017-78-5 5-Cyano-6-oxo-2-phenyl-1,6-dihydro-pyridine-3-carboxylic acid ethyl ester 
• 66129-60-0 ethyl-3-(dimethylamino)-2-(phenylcarbonyl)prop-2-enoate 
• 1131-80-2 (E)-3-(N,N-dimethylamino)-1-phenyl-2-propen-1-one 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 

Downstream Products

• 30517-31-8 3-cyano-6-phenylpyrimidin-2-yl diisopropyl phosphate 
• 1242622-26-9 3-cyano-6-phenylpyridin-2-yl acetate 
• 30645-52-4 3-cyano-6-phenylpyridin-2-yl diethyl phosphate 
• 56162-63-1 2-oxo-6-phenyl-1,2-dihydropyridine-3-carboxylic acid 
• 147269-09-8 2-[3-benzyloxycarbonylamino-6-(4-methoxyphenyl)-2-oxo-1,2-dihydro-1-pyridyl]-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide 
• 147269-02-1 2-<3-<(benzyloxycarbonyl)amino>-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl>-N-<2-<(tert-butyldimethylsilyl)oxy>-3,3,3-trifluoro-1-isopropylpropyl>acetamide 
• 296797-34-7 methyl 3-amino-6-phenylthieno[2,3-b]pyridine-2-carboxylate 
• 147269-10-1 2-[3-benzyloxycarbonylamino-6-(4-methoxyphenyl)-2-oxo-1,2-dihydro-1-pyridyl]-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)acetamide 
• 147267-17-2 2-<3-<(benzyloxycarbonyl)amino>-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl>-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide 
• 147269-03-2 2-<3-<(benzyloxycarbonyl)amino>-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl>-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)acetamide 
• 147283-34-9 2-(3-amino-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl)-N-<2-<(tert-butyldimethylsilyl)oxy>-3,3,3-trifluoro-1-isopropylpropyl>acetamide 

Relevant academic research and scientific papers

2-Chloro-3-cyano-6-phenylpyridine

The molecular structure of the title compound (2-chloro-6-phenylpyridine-3-carbonitrile, C12H7ClN2) is presented. The molecule is nearly planar. Despite strong substituent interactions, the aromaticity of the pyridine frag

About the reaction of β-dimethylamino-α,β-enones with active methylene nitriles

(Chemical Equation Presented) The reaction of 3-dimethylamino-1- arylpropenone derivatives with active methylene nitriles was reinvestigated and a plausible mechanism to account for the results is suggested. X-ray crystallographic study supported the sugg

MODULATORS OF HSD17B13 AND METHODS OF USE THEREOF

The disclosure relates to compounds and pharmaceutical compositions capable of modulating the hydroxysteroid 17-beta dehydrogenase (HSD17B) family member proteins including inhibiting the HSD17B member proteins, e.g. HSD17B13. The disclosure further relates to methods of treating liver diseases, disorders, or conditions with the compounds and pharmaceutical compositions disclosed herein, in which the HSD17B family member protein plays a role.

Base-catalysed 18F-labelling of trifluoromethyl ketones. Application to the synthesis of 18F-labelled neutrophil elastase inhibitors

A new method for the fluorine-18 labelling of trifluoromethyl ketones has been developed. This method is based on the conversion of a-COCF3 functional group to a difluoro enol silyl ether followed by halogenation and fluorine-18 labelling. The utility of this new method was demonstrated by the synthesis of fluorine-18 labelled neutrophil elastase inhibitors, which are potentially useful for detection of inflammatory disorders.

Discovery and structure-activity relationships study of novel thieno[2,3-b]pyridine analogues as hepatitis C virus inhibitors

Current treatment for hepatitis C is barely satisfactory, there is an urgent need to develop novel agents for combating hepatitis C virus infection. This study discovered a new class of thieno[2,3-b]pyridine derivatives as HCV inhibitors. First, a hit compound characterized by a thienopyridine core was identified in a cell-based screening of our privileged small molecule library. And then, structure activity relationship study of the hit compound led to the discovery of several potent compounds without obvious cytotoxicity in vitro (12c, EC50 = 3.3 μM, SI >30.3, 12b, EC50 = 3.5 μM, SI >28.6, 10l, EC50 = 3.9 μM, SI >25.6, 12o, EC 50 = 4.5 μM, SI >22.2, respectively). Although the mechanism of them had not been clearly elucidated, our preliminary optimization of this class of compounds had provided us a start point to develop new anti-HCV agents.

Enaminones as building blocks in heterocyclic syntheses: Reinvestigating the product structures of enaminones with malononitrile. A novel route to 6-substituted-3-oxo-2,3-dihydropyridazine-4-carboxylic acids

The reported structures of reaction products of enaminones with malononitrile in ethanolic piperidine are revised. A novel route to 2,3-dihydropyridazine-4-carboxylic acids 4a-c via reactions of 2-cyano-5-(dimethylamino)-5-arylpenta-2,4-dienamides 8a-c wi

Is the herbicidal activity of 3-cyanopyridin-2-yl phosphates related to phosphatase?

The herbicidal activity of 3-cyanopyridin-2-yl phosphates, which were designed according to the idea of a mechanism-based inactivator, is probably related to a phosphatase. Taylor & Francis Group, LLC.

6-Aryl-pyrazolo[3,4-b]pyridines: Potent inhibitors of glycogen synthase kinase-3 (GSK-3)

A novel series of 6-aryl-pyrazolo[3,4-b]pyridines has been identified that are potent inhibitors of glycogen synthase kinase-3 (GSK-3).

Synthesis of N-glycosylated pyridines as new antimetabolite agents

Condensation of cyanoacetamide and cyanothioacetamide with the sodium salts of α-(hydroxymethylene)alkanones afforded the pyridine-2(1H)-ones and their corresponding thiones 3. Compounds 3 served as a key intermediates for the synthesis of N-glycosylated pyridines.

HETEROCYCLIC AMIDE COMPOUNDS AND PHARMACEUTICAL USE OF THE SAME

Heterocyclic amide compounds of the formula (I) STR1 wherein each symbol is as defined in the specification, pharmacologically acceptable salts thereof, pharmaceutical compositions thereof and pharmaceutical use thereof. The heterocyclic amide compounds and pharmacologically acceptable salts thereof of the present invention have superior inhibitory activity against chymase groups in mammals inclusive of human, and can be administered orally or parenterally. Therefore, they are useful as chymase inhibitors and can be effective for the prophylaxis and treatment of various diseases caused by chymase, such as those caused by angiotensin II.