69751-90-2

Basic information

• Product Name: Benzenesulfonamide, N-(4-chlorophenyl)-N-methyl-4-nitro-
• CAS NO: 69751-90-2
• Molecular Formula: C13H11ClN2O4S
• Molecular Weight: 326.76
• Mol File: 69751-90-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzenesulfonamide, N-(4-chlorophenyl)-N-methyl-4-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonamide, N-(4-chlorophenyl)-N-methyl-4-nitro-(69751-90-2)
• EPA Substance Registry System: Benzenesulfonamide, N-(4-chlorophenyl)-N-methyl-4-nitro-(69751-90-2)

Safety Data

• Hazardous Substances Data: 69751-90-2(Hazardous Substances Data)

Upstream product

• 16937-03-4 N-(4-chlorophenyl)-4-nitrobenzenesulfonamide 
• 74-88-4 methyl iodide 
• 6319-45-5 N-methyl-4-nitro-benzenesulfonamide 
• 108-90-7 chlorobenzene 

Relevant articles and documents

Analgesic agents without gastric damage: Design and synthesis of structurally simple benzenesulfonanilide-type cyclooxygenase-1-selective inhibitors

In order to create novel analgesic agents without gastric disturbance, structurally simple cyclooxygenase-1 (COX-1) inhibitors with a benzenesulfonanilide skeleton were designed and synthesized. As a result, compounds 11f and 15a, which possess a p-amino group on the benzenesulfonyl moiety and p-chloro group on the anilino moiety, showed COX-1-selective inhibition. Moreover compound 11f, which is the most potent compound in this study showed more potent analgesic activity than that of aspirin at 30 mg/kg by po. The anti-inflammatory activity and gastric damage, however, were very weak or not detectably different from aspirin. Since the structure of our COX-1 inhibitors are very simple, they may be useful as lead compounds for superior COX-1 inhibitors as analgesic agents without gastric disturbance.