69762-22-7Relevant academic research and scientific papers
N,N′-(Hexane-1,6-diyl)bis(4-methyl-N-(oxiran-2-ylmethyl) benzenesulfonamide): Synthesis via cyclodextrin mediated N-alkylation in aqueous solution and further Prilezhaev epoxidation
Fischer, Julian,Millan, Simon,Ritter, Helmut
, p. 2834 - 2840 (2013)
N-alkylation of N,N′-(hexane-1,6-diyl)bis(4-methylbenzenesulfonamide) with allyl bromide and subsequent Prilezhaev reaction with m-chloroperbenzoic acid to give N,N′-(hexane-1,6-diyl)bis(4-methyl-N-(oxiran-2-ylmethyl) benzenesulfonamide) is described. Thi
N,N′-(hexane-1,6-diyl)bis(N-((1-aryl/alkyl-1H-1,2,3-triazol-4-yl)methyl)-4-methyl benzenesulfonamide): Synthesis, antibacterial, antioxidant, and DNA-cleavage activities
Reddy, Nagavelli Vasudeva,Narsimha, Sirassu,Sudhakar, Lavudya,Battula, Kumara Swamy,Althaf Hussain
, p. 1118 - 1122 (2016)
Thirteen novel bis-1,2,3-triazole derivatives were synthesized under copper (I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition of N,N′-(hexane-1,6-diyl)bis(4-methyl-N-(prop-2-yn-1-yl)benzenesulfonamide) with different aryl azides and evaluated their bio
A novel and efficient solvent-free and heterogeneous method for the synthesis of primary, secondary and bis-N-acylsulfonamides using metal hydrogen sulfate catalysts
Massah, Ahmad Reza,Asadi, Beheshteh,Hoseinpour, Mahdieh,Molseghi, Azadeh,Kalbasi, Roozbeh Javad,Javaherian Naghash, Hamid
body text, p. 7696 - 7705 (2009/12/04)
Some metal hydrogen sulfates were used as acid catalysts in the N-acylation of different sulfonamides using carboxylic acid chlorides and anhydrides as acylating agents under both heterogeneous and solvent-free conditions. Al(HSO4)3
Allosteric modulators of the tertiary alkanebisamino-type. Variation of the substitution of the middle chain nitrogens
Pick, Rainer,Duda-Johner, Seraina,Traenkle, Christian,Mohr, Klaus,Holzgrabe, Ulrike
, p. 1539 - 1556 (2007/10/03)
Synthesis pathways of high flexibility for variously substituted alkanebisamine-type allosteric modulators of muscarinic receptors capable of passing the blood-brain barrier were developed starting either from N,N′-(hexane-1,6-diyl)bistosylamide or adipic
Convenient synthesis of large tetraazamacrocycles bearing alkylene, cyclophane and crown ether type skeletons
Tomohiro,Ahmadi Avval,Okuno
, p. 639 - 640 (2007/10/02)
A series of large tetraazamacrocycles with 28- to 44-membered rings consisting of alkylene, phenylene or ether type backbones has been prepared without the use of high-dilution conditions in practically significant yields (25-42%). The reaction can be car
Synthesis of Large Macrocyclic Tetraaza Compounds with A Methylene Backbone: Cyclo4, (n = 6,7,8,9 and 10). The Formation of 28-, 32-, 36-, 40- and 44-Membered Rings.
Tomohiro, Takenori,Uoto, Kouichi,Okuno, Hiroaki (Yohmei)
, p. 1233 - 1239 (2007/10/02)
A series of macrocyclic tetraamines with 28-, 32-, 36-, 40- and 44-membered rings have been efficiently prepared from the corresponding ditosylamide and monobromoalcohol derivatives in 6 steps via a double condensation reaction.Overall yields were: 41, 41, 46, 29, and 33 percent, respectively, for 1,8,15,22-tetraazacyclooctacontane (11a), 1,9,17,25-tetraazacyclodotriacontane (11b), 1,10,19,28, tetraazacyclohexatriacontane (11c), 1,11,21,31-tetraazacyclotetracontane (11d) and 1,12,23,34-tetraazacyclotetratetracontane (11e).
Chemical differentiating agents. Differentiation of HL-60 cells by hexamethylenebis[acetamide] analogues
Haces, Alberto,Breitman, Theodore R.,Driscoll, John S.
, p. 405 - 409 (2007/10/02)
Hexamethylenebis[acetamide] (HMBA) is an agent in clinical trial that induces differentiation of certain types of tumor cells to nonmalignant phenotypes. In an attempt to discover a more potent compound, a number of bis-functionalized amides, imides, and hydrazine derivatives of HMBA were prepared and evaluated in vitro with the HL-60 human promyelocytic leukemia cell line. Among the compounds evaluated, the 5,5-dimethylhydantoin derivative is almost 10 times more potent than HMBA in inducing differentiation. The bis-imide, diacetyl-HMBA is both more potent and effective than its parent compound. Six of the 16 compounds evaluated cause at least 20% differentiation. An inverse relationship between the degree of differentiation and the percentage of viable cells is described for HMBA and its analogues.
Preferential Introduction of a Pyridylmethyl Group into Sulfonamides as an Approach to an Intramolecular Transimination
Iwata, Masaaki,Kuzuhara, Hiroyoshi
, p. 2153 - 2157 (2007/10/02)
N,N'-Bis(p-tolylsulfonyl)-α,ω-alkanediamine disodium salts (n=3, 4, 5, 6, 7, 8, 9, 10) were subjected to monopyridylmethylation by the reaction with 5'-deoxy-5'-chloro- or 5'-deoxy-2'-chloro-3,4'-O-isopropylidenepyridoxine hydrochloride, accompanied by th
