69762-22-7

Upstream product

• 124-09-4 1,6-Hexanediamine 
• 98-59-9 p-toluenesulfonyl chloride 
• 629-03-8 1 ,6-dibromohexane 
• 70-55-3 toluene-4-sulfonamide 

Downstream Products

• 115368-16-6 C₂₂H₃₂N₂O₅S₂ 
• 187839-64-1 1,8,15-Tris-(toluene-4-sulfonyl)-1,8,15-triaza-cyclohenicosane 
• 124-09-4 1,6-Hexanediamine 
• 80958-65-2 N²,N⁹-di-p-toluenesulfonyl-15-hydroxy-16-hydroxymethyl-15,16'-O-isopropylidene-2,9-diaza<10>(2,5)pyridinophane 
• 1189567-35-8 C₂₈H₄₀N₂O₆S₂ 
• 1189567-36-9 C₃₀H₄₄N₂O₆S₂ 

Relevant academic research and scientific papers

N,N′-(Hexane-1,6-diyl)bis(4-methyl-N-(oxiran-2-ylmethyl) benzenesulfonamide): Synthesis via cyclodextrin mediated N-alkylation in aqueous solution and further Prilezhaev epoxidation

N-alkylation of N,N′-(hexane-1,6-diyl)bis(4-methylbenzenesulfonamide) with allyl bromide and subsequent Prilezhaev reaction with m-chloroperbenzoic acid to give N,N′-(hexane-1,6-diyl)bis(4-methyl-N-(oxiran-2-ylmethyl) benzenesulfonamide) is described. Thi

N,N′-(hexane-1,6-diyl)bis(N-((1-aryl/alkyl-1H-1,2,3-triazol-4-yl)methyl)-4-methyl benzenesulfonamide): Synthesis, antibacterial, antioxidant, and DNA-cleavage activities

Thirteen novel bis-1,2,3-triazole derivatives were synthesized under copper (I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition of N,N′-(hexane-1,6-diyl)bis(4-methyl-N-(prop-2-yn-1-yl)benzenesulfonamide) with different aryl azides and evaluated their bio

A novel and efficient solvent-free and heterogeneous method for the synthesis of primary, secondary and bis-N-acylsulfonamides using metal hydrogen sulfate catalysts

Some metal hydrogen sulfates were used as acid catalysts in the N-acylation of different sulfonamides using carboxylic acid chlorides and anhydrides as acylating agents under both heterogeneous and solvent-free conditions. Al(HSO4)3

Allosteric modulators of the tertiary alkanebisamino-type. Variation of the substitution of the middle chain nitrogens

Synthesis pathways of high flexibility for variously substituted alkanebisamine-type allosteric modulators of muscarinic receptors capable of passing the blood-brain barrier were developed starting either from N,N′-(hexane-1,6-diyl)bistosylamide or adipic

Convenient synthesis of large tetraazamacrocycles bearing alkylene, cyclophane and crown ether type skeletons

A series of large tetraazamacrocycles with 28- to 44-membered rings consisting of alkylene, phenylene or ether type backbones has been prepared without the use of high-dilution conditions in practically significant yields (25-42%). The reaction can be car

Synthesis of Large Macrocyclic Tetraaza Compounds with A Methylene Backbone: Cyclo4, (n = 6,7,8,9 and 10). The Formation of 28-, 32-, 36-, 40- and 44-Membered Rings.

A series of macrocyclic tetraamines with 28-, 32-, 36-, 40- and 44-membered rings have been efficiently prepared from the corresponding ditosylamide and monobromoalcohol derivatives in 6 steps via a double condensation reaction.Overall yields were: 41, 41, 46, 29, and 33 percent, respectively, for 1,8,15,22-tetraazacyclooctacontane (11a), 1,9,17,25-tetraazacyclodotriacontane (11b), 1,10,19,28, tetraazacyclohexatriacontane (11c), 1,11,21,31-tetraazacyclotetracontane (11d) and 1,12,23,34-tetraazacyclotetratetracontane (11e).

Chemical differentiating agents. Differentiation of HL-60 cells by hexamethylenebis[acetamide] analogues

Hexamethylenebis[acetamide] (HMBA) is an agent in clinical trial that induces differentiation of certain types of tumor cells to nonmalignant phenotypes. In an attempt to discover a more potent compound, a number of bis-functionalized amides, imides, and hydrazine derivatives of HMBA were prepared and evaluated in vitro with the HL-60 human promyelocytic leukemia cell line. Among the compounds evaluated, the 5,5-dimethylhydantoin derivative is almost 10 times more potent than HMBA in inducing differentiation. The bis-imide, diacetyl-HMBA is both more potent and effective than its parent compound. Six of the 16 compounds evaluated cause at least 20% differentiation. An inverse relationship between the degree of differentiation and the percentage of viable cells is described for HMBA and its analogues.

Preferential Introduction of a Pyridylmethyl Group into Sulfonamides as an Approach to an Intramolecular Transimination

N,N'-Bis(p-tolylsulfonyl)-α,ω-alkanediamine disodium salts (n=3, 4, 5, 6, 7, 8, 9, 10) were subjected to monopyridylmethylation by the reaction with 5'-deoxy-5'-chloro- or 5'-deoxy-2'-chloro-3,4'-O-isopropylidenepyridoxine hydrochloride, accompanied by th