697739-05-2

Basic information

• Product Name: 6-FLUORO-4-INDAZOLECARBOXYLIC ACID METHYL ESTER
• Synonyms: 6-FLUORO-4-INDAZOLECARBOXYLIC ACID METHYL ESTER;6-FLUOROINDAZOLE-4-METHYL CARBOXYLATE;1H-Indazole-4-carboxylic ...;1H-Indazole-4-carboxylic acid, 6-fluoro-, Methyl ester;METHYL-6-FLUORO-IH-INDAZOLE-4-CARBOXYLATE;Methyl 6-fluoro-1H-indazole-4-carboxylate
• CAS NO: 697739-05-2
• Molecular Formula: C9H7FN2O2
• Molecular Weight: 194.16
• Mol File: 697739-05-2.mol

Chemical Properties

• Boiling Point: 357.6±27.0 °C(Predicted)
• Appearance: /
• Density: 1.415±0.06 g/cm3(Predicted)
• PKA: 11?+-.0.40(Predicted)
• CAS DataBase Reference: 6-FLUORO-4-INDAZOLECARBOXYLIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 6-FLUORO-4-INDAZOLECARBOXYLIC ACID METHYL ESTER(697739-05-2)
• EPA Substance Registry System: 6-FLUORO-4-INDAZOLECARBOXYLIC ACID METHYL ESTER(697739-05-2)

Safety Data

• Hazardous Substances Data: 697739-05-2(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
6-Fluoro-4-indazolecarboxylic Acid Methyl Ester is used as a building block for the synthesis of various organic compounds. Its presence in the structure of these compounds can impart unique properties and reactivity, making it a valuable component in the development of new materials and products.
Used in Esterification Processes:
6-Fluoro-4-indazolecarboxylic Acid Methyl Ester is used as a reagent in the process of esterification, where it can react with an alcohol to form an ester. This reaction is important in the production of esters that have specific applications in various industries, such as pharmaceuticals, fragrances, and flavorings.
Used in Pharmaceutical Industry:
6-Fluoro-4-indazolecarboxylic Acid Methyl Ester is used as a key intermediate in the synthesis of pharmaceutical compounds. Its unique structure and reactivity can contribute to the development of new drugs with improved efficacy and reduced side effects.
Used in Research and Development:
6-Fluoro-4-indazolecarboxylic Acid Methyl Ester is used as a research compound in academic and industrial laboratories. Its properties and reactivity are studied to gain insights into the behavior of fluorinated indazoles and their potential applications in various fields.

Upstream product

• 697739-04-1 3-amino-5-fluoro-2-methylbenzoic acid methyl ester 
• 67-56-1 methanol 

Relevant articles and documents

A 6 - fluoro - 1H - indazole - 4 - carboxylic acid methyl ester preparation method (by machine translation)

The invention relates to a 6 - fluoro - 1H - indazole - 4 - carboxylic acid methyl ester of the new method, the reaction process is simple, high safety, high yield, and can be mass production. (by machine translation)

HETEROAROMATIC UREAS WHICH MODULATE THE FUNCTION OF THE VANILLOID-1 RECEPTOR (VR1)

Compounds of formula (I): are useful as therapeutic compounds, particularly in the treatment of pain and other conditions ameliorated by the modulation of the function of the vanilloid-1 receptor (VR1).

AMINO-HETEROCYCLES AS VR-1 ANTAGONISTS FOR TREATING PAIN

the present invention provides a compound of formula (I): wherein V represents NR5, O, S, SO or S(O)2; W and X each independently represent CH or N; Y represents N, CH or C-Ar2, with the proviso that at least one, but no more than two, of W, X and Y are N; Z represents CH or C-Ar2, with the proviso that when Y is N or CH then Z is C-Ar2, and with the further proviso that when Y is C-Ar2 then Z is CH; Ar1 represents a fused 9 or 10 membered heterobicyclic ring system containing one, two, three or four heteroatoms selected from nitrogen, oxygen and sulfur, wherein at least one of the rings in said ring system is aromatic; Ar2 represents an aromatic ring selected from phenyl, pyridyl, pyrimidinyl and pyridazinyl which is optionally fused and substituted; R1 represents halogen, hydroxy, oxo, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, haloC1-6alkyl, hydroxyC1-6alkyl, C1-6alkoxy, haloC1-6alkoxy, hydroxyC1-6alkoxy, C3-7cycloalkyl, C3-7cycloalkoxy, C3-5cycloalkylC1-4alkyl, cyano, nitro, SR6, SOR6, SO2R6, COR6, NR3COR6, CONR3R4, NR3SO2R6, SO2NR3R4, -(CH2)mcarboxy, esterified -(CH2)mcarboxy or -(CH2)mNR3R4; R2 represents hydrogen, halogen, hydroxy, C1-6alkyl, haloC1-6alkyl, C3-7cycloalkyl, C1-6alkoxy, haloC1-6alkoxy, unsubstituted phenyl or phenyl substituted with one or two groups selected from halogen, C1-6alkyl, haloC1-6alkyl, C3-7cycloalkyl, C1-6alkoxy or haloC1-6alkoxy; R3 and R4 are each independently hydrogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-7cycloalkyl or fluoroC1-6alkyl; or R3 and R4 and the nitrogen atom to which they are attached together form a heteroaliphatic ring of 4 to 7 ring atoms, optionally substituted by one or two groups selected from hydroxy or C1-4alkoxy, which ring may optionally contain as one of the said ring atoms an oxygen or a sulfur atom, S(O), S(O)2, or NR5; R5 represents hydrogen, C1-4alkyl, hydroxyC1-4alkyl or C1-4alkoxyC1-4alkyl; R6 represents hydrogen, C1-6alkyl, fluoroC1-6alkyl, C3-7cycloalkyl, unsubstituted phenyl, or phenyl substituted with one or two groups selected from halogen, C1-6alkyl, haloC1-6alkyl, C3-7cycloalkyl, C1-6alkoxy or haloC1-6alkoxy; m is either zero or an integer from 1 to 4; n is either zero or an integer from 1 to 3; or a pharmaceutically acceptable salt, N-oxide or a prodrug thereof; a pharmaceutical composition comprising it; its use in methods of treatment; use of it for the manufacture of a medicament for treating VR-1 related conditions such as those in which pain and/or inflammation predominate; and methods of treatment using it.