697739-05-2

Basic information

• Product Name: 6-FLUORO-4-INDAZOLECARBOXYLIC ACID METHYL ESTER
• Synonyms: 6-FLUORO-4-INDAZOLECARBOXYLIC ACID METHYL ESTER;6-FLUOROINDAZOLE-4-METHYL CARBOXYLATE;1H-Indazole-4-carboxylic ...;1H-Indazole-4-carboxylic acid, 6-fluoro-, Methyl ester;METHYL-6-FLUORO-IH-INDAZOLE-4-CARBOXYLATE;Methyl 6-fluoro-1H-indazole-4-carboxylate
• CAS NO: 697739-05-2
• Molecular Formula: C9H7FN2O2
• Molecular Weight: 194.16
• Mol File: 697739-05-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 357.6±27.0 °C(Predicted)
• Appearance: /
• Density: 1.415±0.06 g/cm3(Predicted)
• PKA: 11?+-.0.40(Predicted)
• CAS DataBase Reference: 6-FLUORO-4-INDAZOLECARBOXYLIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 6-FLUORO-4-INDAZOLECARBOXYLIC ACID METHYL ESTER(697739-05-2)
• EPA Substance Registry System: 6-FLUORO-4-INDAZOLECARBOXYLIC ACID METHYL ESTER(697739-05-2)

Safety Data

• Hazardous Substances Data: 697739-05-2(Hazardous Substances Data)

Usage

General Description

6-Fluoro-4-indazolecarboxylic Acid Methyl Ester is a chemical compound that belongs to the class of organic compounds known as indazoles. As a fluorinated compound, this substance contains an atom of fluorine. It is commonly used in the field of organic synthesis, serving as an essential building block in the production of a variety of different products. The methyl ester part of its structure suggests that it might also be utilized as a reagent in the process of esterification, which forms an ester as the reaction product. Like many other organic compounds, it is relatively stable but should be handled under appropriate safety measures due to its potential reactivity.

Upstream product

• 67-56-1 methanol 
• 697739-04-1 3-amino-5-fluoro-2-methylbenzoic acid methyl ester 

Relevant articles and documents

A 6 - fluoro - 1H - indazole - 4 - carboxylic acid methyl ester preparation method (by machine translation)

The invention relates to a 6 - fluoro - 1H - indazole - 4 - carboxylic acid methyl ester of the new method, the reaction process is simple, high safety, high yield, and can be mass production. (by machine translation)

AMINO-HETEROCYCLES AS VR-1 ANTAGONISTS FOR TREATING PAIN

the present invention provides a compound of formula (I): wherein V represents NR5, O, S, SO or S(O)2; W and X each independently represent CH or N; Y represents N, CH or C-Ar2, with the proviso that at least one, but no more than two, of W, X and Y are N; Z represents CH or C-Ar2, with the proviso that when Y is N or CH then Z is C-Ar2, and with the further proviso that when Y is C-Ar2 then Z is CH; Ar1 represents a fused 9 or 10 membered heterobicyclic ring system containing one, two, three or four heteroatoms selected from nitrogen, oxygen and sulfur, wherein at least one of the rings in said ring system is aromatic; Ar2 represents an aromatic ring selected from phenyl, pyridyl, pyrimidinyl and pyridazinyl which is optionally fused and substituted; R1 represents halogen, hydroxy, oxo, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, haloC1-6alkyl, hydroxyC1-6alkyl, C1-6alkoxy, haloC1-6alkoxy, hydroxyC1-6alkoxy, C3-7cycloalkyl, C3-7cycloalkoxy, C3-5cycloalkylC1-4alkyl, cyano, nitro, SR6, SOR6, SO2R6, COR6, NR3COR6, CONR3R4, NR3SO2R6, SO2NR3R4, -(CH2)mcarboxy, esterified -(CH2)mcarboxy or -(CH2)mNR3R4; R2 represents hydrogen, halogen, hydroxy, C1-6alkyl, haloC1-6alkyl, C3-7cycloalkyl, C1-6alkoxy, haloC1-6alkoxy, unsubstituted phenyl or phenyl substituted with one or two groups selected from halogen, C1-6alkyl, haloC1-6alkyl, C3-7cycloalkyl, C1-6alkoxy or haloC1-6alkoxy; R3 and R4 are each independently hydrogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-7cycloalkyl or fluoroC1-6alkyl; or R3 and R4 and the nitrogen atom to which they are attached together form a heteroaliphatic ring of 4 to 7 ring atoms, optionally substituted by one or two groups selected from hydroxy or C1-4alkoxy, which ring may optionally contain as one of the said ring atoms an oxygen or a sulfur atom, S(O), S(O)2, or NR5; R5 represents hydrogen, C1-4alkyl, hydroxyC1-4alkyl or C1-4alkoxyC1-4alkyl; R6 represents hydrogen, C1-6alkyl, fluoroC1-6alkyl, C3-7cycloalkyl, unsubstituted phenyl, or phenyl substituted with one or two groups selected from halogen, C1-6alkyl, haloC1-6alkyl, C3-7cycloalkyl, C1-6alkoxy or haloC1-6alkoxy; m is either zero or an integer from 1 to 4; n is either zero or an integer from 1 to 3; or a pharmaceutically acceptable salt, N-oxide or a prodrug thereof; a pharmaceutical composition comprising it; its use in methods of treatment; use of it for the manufacture of a medicament for treating VR-1 related conditions such as those in which pain and/or inflammation predominate; and methods of treatment using it.