69790-45-0

Upstream product

• 1517-63-1 4-methylphenyl(phenyl)methanol 
• 98-88-4 benzoyl chloride 
• 24388-23-6 2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole 
• 3262-89-3 triphenylboroxine 
• 1612226-02-4 N-(tert-butylperoxy(p-tolyl)methyl)benzamide 
• 100-58-3 phenylmagnesium bromide 
• 65608-94-8 N-(p-methylbenzyl)benzamide 
• 87100-32-1 2-[chloro(phenyl)methyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 867182-07-8 N-[phenyl(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl]benzamide 
• 106-38-7 para-bromotoluene 
• 55-21-0 benzamide 
• 5720-05-8 4-methylphenylboronic acid 
• 100-52-7 benzaldehyde 

Relevant academic research and scientific papers

Method for synthesizing amide compound by taking nitrile and diaryl methane as raw materials

The invention discloses a method for synthesizing an amide compound by taking nitrile and diaryl methane as raw materials, the method comprises the following steps: taking diaryl methane as a reaction raw material, nitrile as a raw material and a solvent, 2, 3-dichloro-5, 6-dinitrile group-1, 4-benzoquinone (DDQ) and tert-butyl nitrite (TBN) as catalysts, acid as an auxiliary agent and oxygen as an oxidizing agent, reacting under the conditions of normal temperature, normal pressure and blue light irradiation, and after the reaction is finished, carrying out separation treatment to obtain the amide compound. According to the method, the problem of metal residues in the product can be solved, oxygen is used as a terminal oxidizing agent, the method is environmentally friendly, and energy can be saved.

A palladium-catalyzed arylation of N-acyl-N,O-acetals with arylboronic reagents: Synthesis of diarylmethylamines protected by easily removable acyl group

An efficient process was developed to synthesis diarylmethylamines protected by a readily removable acyl group using a palladium-catalyzed arylation of N-acyl-N,O-acetals with arylboronic reagents. The attractive features of this protocol are: the ease of

Peroxidation of C-H bonds adjacent to an amide nitrogen atom under mild conditions

Under mild conditions, the oxidative functionalization of C-H bonds adjacent to an amide nitrogen atom was achieved. tert-Butylperoxyamido acetal was obtained in high yields and could be further converted into α-substituted amides by treatment with Grigna

A Lewis acid palladium(II)-catalyzed three-component synthesis of α-substituted amides

A Lewis acid palladium-catalyzed reaction of amides, aryl aldehydes, and arylboronic acids is described. This new method allows for a practical and general synthesis of α-substituted amides from simple, readily available building blocks.

Amberlyst-15 in ionic liquid: An efficient and recyclable reagent for nucleophilic substitution of alcohols and hydroamination of alkenes

The nucleophilic substitution reaction of secondary alcohols and hydroamination of alkenes with amides, sulfonamides, carbamates, and amines using Amberlyst-15 immobilized in [Bmim][BF4] (1-butyl-3- methylimidazolium tetrafluoroborate) ionic liquid as an efficient recyclable reagent is described. The solvent effect is prominent in the reaction, and the desired substitution products are obtained in good to excellent yield. The protocol is advantageous due to the ease of handling of the reagents, the simple work-up procedure, and the environmentally benign conditions that allow effective recyclability. A facile protocol involving Amberlyst-15 in the ionic liquid [Bmim][BF4] (= 1-butyl-3-methylimidazolium tetrafluoroborate) has been developed for nucleophilic substitution of alcohols and hydroamination of alkenes.

α-Amidobenzylation of aryl and alkenyl halides via palladium-catalyzed Suzuki-Miyaura coupling with α-(acylamino) benzylboronic esters

The Suzuki-Miyaura coupling of α-(acetylamino)benzylboronic esters with aryl and alkenyl halides has been achieved using a Pd/P(t-Bu)3 catalyst with KF and H2O in 1,4-dioxane, giving α-substituted benzylamines in high yields. Copyright

Three-component synthesis of amine derivatives using benzylic and allylic alcohols as N-alkylating agents in the absence of external catalysts and additives

The direct employment of benzylic and allylic alcohols as N-alkylating agents provides a useful synthetic route for amine derivatives by avoiding the preactivation of the hydroxy groups of alcohols. Herein we report a novel by-product-catalyzed three-comp

Phosphotungstic acid catalyzed amidation of alcohols

Mild nucleophilic substitution reactions of benzhydrylic, benzylic, allylic, and simple aliphatic alcohols with sulfonamides, benzamide, and 4-nitroaniline in the presence of 12-phosphotungstic acid as an efficient, eco-friendly, cheap, and air- and moisture-tolerant catalyst for the construction of C-N bonds has been investigated. The amine derivatives were obtained in good yields (up to 98%). The reusable nature of the 12-phosphotungstic acid makes this protocol more attractive. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.