69797-47-3

Upstream product

• 292638-85-8 acrylic acid methyl ester 
• 456-48-4 3-Fluorobenzaldehyde 
• 140-88-5 ethyl acrylate 

Downstream Products

• 70631-88-8 4-(3-fluorophenyl)butanoic acid 
• 703-67-3 6-fluoro-3,4-dihydronaphthalen-1(2H)-one 
• 134464-81-6 C₁₁H₁₃FO₂ 
• 1213300-76-5 (R)-(6-phenylsulfanyl-1,2,3,4-tetrahydro-naphthalen-1-yl)-acetic acid methyl ester 
• 895534-22-2 (R)-(6-phenylsulfanyl-1,2,3,4-tetrahydro-naphthalen-1-yl)-acetic acid 
• 895534-14-2 6-benzenesulfonyl-1,2,3,4-tetrahydro-naphthalene-1-carbonitrile 
• 895534-13-1 6-benzenesulfonyl-3,4-dihydro-naphthalene-1-carbonitrile 
• 895132-99-7 6-Benzenesulfonyl-3,4-dihydro-2H-naphthalen-1-one 
• 149915-80-0 6-phenylsulfanyl-3,4-dihydro-2H-naphthalen-1-one 
• 880544-27-4 (6-benzenesulfonyl-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-(4,5-dihydro-1H-imidazol-2-yl)-amine 
• 880544-30-9 C-(6-benzenesulfonyl-1,2,3,4-tetrahydro-naphthalen-1-yl)-methylamine 
• 895534-20-0 (R)-6-phenylsulfanyl-1,2,3,4-tetrahydro-naphthalen-1-ol 

Relevant academic research and scientific papers

Arylsulfonyl naphthalene derivatives and uses thereof

Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, q, Ar, R1, R2 and R7 are as defined herein. Also provided are methods for preparing, compositions comprising, and methods for using compounds of formula I.

TETRALIN AND INDANE DERIVATIVES AND USES THEREOF

Compounds of the formula I, II or III; or pharmaceutically acceptable salts thereof, wherein m, n, q, Ar, R1, R2, R3, R4 and R5 are as defined herein. Also provided are methods for preparing, compositions comprising, and methods for using compounds of formulas I-III.

TETRALIN AND INDANE DERIVATIVES AND USES THEREOF AS 5-HT ANTAGONISTS

Compounds of the formula (I) or pharmaceutically acceptable salts thereof, wherein m, p, q, Ar, R1 and R 2 are as defined herein. Also provided are methods for preparing, compositions comprising, and methods for using compounds of formula (I).

TETRALIN AND INDANE DERIVATIVES AND USES THEREOF

Compounds of the formula (I), or pharmaceutically acceptable salts thereof, wherein R2 is (CR3R4)n-NR5R6 and m, p, q, Ar, R1, R3, R4, R5 and R6 are as defined in the claims, which are selective antagonists of 5-HT6 and/or 5-HT2A. Also provided are compositions comprising these compounds and their use in the preparation of medicaments for treating central nervous system disease states selected from psychoses, schizophrenia, manic depressions, neurological disorders, memory disorders, attention deficit disorder, Parkinson’s disease, amyotrophic lateral scierosis, Alzheimer’s disease, food uptake disorders and Huntington’s disease.

TETRALIN AND INDANE DERIVATIVES AND USES THEREOF

Compounds of the formula (I) or pharmaceutically acceptable salts thereof, wherein R2 is a group of formula (II) and m, n, p, q, r, Rl and X are as defined in the claims, which are selective agonists of 5-HT6 and 5-HT2A. Also provided are compositions comprising these compounds and methods for their use in the preparation of medicaments for treating central nervous system disease states and disorders of the gastrointestinal tract.

Aminomethylcarboxylic acid derivatives

The present invention relates to aminomethylcarboxylic acid derivatives general formula (I), wherein Z is (CH2)n, O, S, SO, SO2or N—R5; n is 0, 1 or 2; X represents 1-3 substituents independently selected from hydrogen, halogen, (C1-6)alkyloxy, (C3-6)cycloalkyloxy, (C6-12)aryloxy, (C6-12)aryl, thienyl, SR6, SOR6, SO2R6, NR6R6, NHR6, NH2, NHCOR6, NSO2R6, CN, COOR6and (C1-4)alkyl, optionally substituted with halogen, (C6-12)aryl, (C1-6)alkyloxy or (C6-12)aryloxy; or 2 substituents at adjacent positions together represent a fused (C5-6)aryl group, a fused (C5-6)cycloalkyl ring or O—(CH2)m—O; m is 1 or 2; Y represents 1-3 substituents independently selected from hydrogen, halogen, (C1-4)alkyloxy, SR6, NR6R6and (C1-4)alkyl, optionally substituted with halogen; R1is COOR7or CONR8R9; R2and R6are (C1-4)alkyl; R3, R4and R5are independently hydrogen or (C1-4)alkyl; R7, R8and R9are independently hydrogen, (C1-4)alkyl, (C6-12)aryl or arylalkyl; or a pharmaceutically acceptable salt thereof. The invention also relates to pharmaceutical compositions comprising said derivatives, as well as to the use of these aminomethylcarboxylic acid derivatives in therapy, more specifically for the treatment of CNS disorders.

Synthesis of 3-aminomethyl-1-tetralones as potential neuroleptic agents

3-Aminomethyl tetralones, which present the butyrophenone side chain partially incorporated in a semirigid structure have been prepared by Mannich reaction of β-benzoyl-propionic acids and heterocyclic amines, catalytic reduction of the carbonyl group and