6983-36-4Relevant articles and documents
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Niemann,Hays
, p. 2960 (1940)
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Direct preparation of N-glycosidic bond-linked nonionic carbohydrate-based surfactant (NICBS) via ritter reaction
Wang, Zerong Daniel,Sheikh, Samia O.,Cox, Shannon,Zhang, Yulu,Massey, Keegan
, p. 2243 - 2247 (2007)
The Ritter reaction has been successfully extended to the direct preparation of N-glycosidic bond-linked nonionic carbohydrate-based surfactants from carbohydrates and nitriles in the presence of trimethylsilyl trifluoromethanesulfonate (TMSOTf) and silve
Method of producing an amide
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Page/Page column 2; 9, (2008/06/13)
The present invention discloses a new method for synthesizing an amide based on a fundamental mechanistic revision of the reaction of thio acids and organic azides. Moreover, the application of this method to the selective preparation of several classes of complex amides in nonpolar and polar solvents, including water, is provided.
The reaction of thio acids with azides: A new mechanism and new synthetic applications
Shangguan, Ning,Katukojvala, Sreenivas,Greenberg, Rachel,Williams, Lawrence J.
, p. 7754 - 7755 (2007/10/03)
A new amide synthesis strategy based on a fundamental mechanistic revision of the reaction of thio acids and organic azides is presented. The data demonstrate that amines are not formed as intermediates in this reaction. Alternative mechanisms proceeding through a thiatriazoline intermediate are suggested. The reaction has been applied to the preparation of simple and architecturally complex amides that are difficult to access using conventional methods. The reaction is chemoselective, effective for unprotected substrates, and compatible with aprotic and protic solvents, including water. Copyright