698351-97-2

Upstream product

• 140175-19-5 Methyl-(2-methyl-1-tributylstannanyl-propyl)-carbamic acid tert-butyl ester 
• 100-52-7 benzaldehyde 
• 698351-32-5 [1-(hydroxy-phenyl-methyl)-2-methyl-propyl]-methyl-carbamic acid tert-butyl ester 

Downstream Products

• 698352-94-2 2-(N-methylamino)-3-methyl-1-phenyl-1-butanone 

Relevant academic research and scientific papers

COMPOSITIONS AND METHODS COMPRISING SUBSTITUTED 2-AMINOIMIDAZOLES

The present invention presents 2-(acylamino)imidazoles with therapeutic activity, including selective activity against cancer cells, and compositions comprising them. Methods of using and preparing the 2-(acylamino)imidazoles are also presented.

Diastereoselective reduction of α-aminoketones: Synthesis of anti- and syn-β-aminoalcohols

Reduction of N-t-BOC-protected-N-alkyl α-aminoketones with LiEt 3BH or Li(S-Bu)3BH furnishes protected syn-β-aminoalcohols with high selectivities. In contrast, removal of the BOC group followed by reduction of the aminoketone gives anti-β- aminoalcohols with variable selectivities. With aromatic ketones, selectivities are typically high while aliphatic ketones show mediocre to high selectivities depending on steric considerations.