698352-94-2Relevant academic research and scientific papers
Diastereoselective reduction of α-aminoketones: Synthesis of anti- and syn-β-aminoalcohols
Fraser, David S.,Park, Sheldon B.,Chong, J. Michael
, p. 87 - 101 (2007/10/03)
Reduction of N-t-BOC-protected-N-alkyl α-aminoketones with LiEt 3BH or Li(S-Bu)3BH furnishes protected syn-β-aminoalcohols with high selectivities. In contrast, removal of the BOC group followed by reduction of the aminoketone gives anti-β- aminoalcohols with variable selectivities. With aromatic ketones, selectivities are typically high while aliphatic ketones show mediocre to high selectivities depending on steric considerations.
