698358-23-5

Upstream product

• 93102-05-7 N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine 
• 623-47-2 propynoic acid ethyl ester 
• 111267-97-1 N-ethyl-N-<(trimethylsilyl)methyl>benzylamine 

Downstream Products

• 1217656-93-3 2-tert-Butyl 3a-Ethyl Tetrahydropyrrolo[3,4-c]pyrrole-2,3a(1H,3H)-dicarboxylate 
• 851526-85-7 Hexahydro-pyrrolo[3,4-c]pyrrole-3a-carboxylic Acid Ethyl Ester 

Relevant academic research and scientific papers

A hexahydro-pyrrolo [3, 4 - c] pyrrole of compound and its preparation method

The invention discloses a phenyl ester spiro pyrrolidine compound and a preparation method thereof, belonging to the technical field of synthesis of spiro compounds. According to the key points of the technical scheme, the phenyl ester spiro pyrrolidine compound has the following structure, wherein the structural formula is as shown in the specification; R refers to -COOCH3, -COOCH2CH3, -COO(CH2)2CH3 or -COOCH(CH3)2. The invention also discloses a preparation method of the phenyl ester spiro pyrrolidine compound. Multiple phenyl ester spiro pyrrolidine compounds are synthesized by virtue of a novel method, and in the preparation process, the process is simple and easy to control, the product yield of the target product is high, and the repeatability is high.

Substituted diazabicycloalkane derivatives

Compounds of formula (I) [in-line-formulae]Z-Ar1—Ar2??(I) [/in-line-formulae] wherein Z is a diazabicyclic amine, Ar1 is a 5- or 6-membered aromatic ring, and Ar2 is selected from the group consisting of an unsubstituted or substituted 5- or 6-membered heteroaryl ring; unsubstituted or substituted bicyclic heteroaryl ring; 3,4-(methylenedioxy)phenyl; carbazolyl; tetrahydrocarbazolyl; naphthyl; and phenyl; wherein the phenyl is substituted with 0, 1, 2, or 3 substituents in the meta- or para-positions. The compounds are useful in treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands. Also disclosed are pharmaceutical compositions comprising compounds of formula (I) and methods for using such compounds and compositions.

A rapid catalytic asymmetric synthesis of 1,3,4-trisubstituted pyrrolidines

The asymmetric synthesis of 1,3,4-trisubstituted pyrrolidines was accomplished in two steps from readily available starting materials. A 1,3-dipolar cycloaddition of an azomethine ylide to a propiolate ester followed by a Rh-catalyzed asymmetric 1,4-arylation of the resulting pyrroline with an arylboronic acid provided the desired 1,3,4-trisubstituted pyrrolidine products in good to excellent enantioselectivities.