1154758-55-0

Basic information

• Product Name: 4-nitrobenzyl (((2S,3R)-2-(((1R,2R,3S,4R,6S)-4-amino-6-((tert-butoxycarbonyl)amino)-3-(((2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(methylamino)tetrahydro-2H-pyran-2-yl)oxy)-2-hydroxycyclohexyl)oxy)-3-((tert-butoxycarbonyl)amino)-3,4-dihydro-2H-pyran-6-yl)methyl)carbamate
• Synonyms: 4-nitrobenzyl (((2S,3R)-2-(((1R,2R,3S,4R,6S)-4-amino-6-((tert-butoxycarbonyl)amino)-3-(((2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(methylamino)tetrahydro-2H-pyran-2-yl)oxy)-2-hydroxycyclohexyl)oxy)-3-((tert-butoxycarbonyl)amino)-3,4-dihydro-2H-pyran-6-yl)methyl)carbamate
• CAS NO: 1154758-55-0
• Molecular Weight: 826.899
• Mol File: 1154758-55-0.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 4-nitrobenzyl (((2S,3R)-2-(((1R,2R,3S,4R,6S)-4-amino-6-((tert-butoxycarbonyl)amino)-3-(((2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(methylamino)tetrahydro-2H-pyran-2-yl)oxy)-2-hydroxycyclohexyl)oxy)-3-((tert-butoxycarbonyl)amino)-3,4-dihydro-2H-pyran-6-yl)methyl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-nitrobenzyl (((2S,3R)-2-(((1R,2R,3S,4R,6S)-4-amino-6-((tert-butoxycarbonyl)amino)-3-(((2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(methylamino)tetrahydro-2H-pyran-2-yl)oxy)-2-hydroxycyclohexyl)oxy)-3-((tert-butoxycarbonyl)amino)-3,4-dihydro-2H-pyran-6-yl)methyl)carbamate(1154758-55-0)
• EPA Substance Registry System: 4-nitrobenzyl (((2S,3R)-2-(((1R,2R,3S,4R,6S)-4-amino-6-((tert-butoxycarbonyl)amino)-3-(((2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(methylamino)tetrahydro-2H-pyran-2-yl)oxy)-2-hydroxycyclohexyl)oxy)-3-((tert-butoxycarbonyl)amino)-3,4-dihydro-2H-pyran-6-yl)methyl)carbamate(1154758-55-0)

Safety Data

• Hazardous Substances Data: 1154758-55-0(Hazardous Substances Data)

Upstream product

• 1154758-54-9 4-nitrobenzyl (((2S,3R)-3-amino-2-(((1R,2S,3S,4R,6S)-4,6-diamino-3-(((2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(methylamino)tetrahydro-2H-pyran-2-yl)oxy)-2-hydroxycyclohexyl)oxy)-3,4-dihydro-2H-pyran-6-yl)methyl)carbamate 
• 86832-06-6 1-{[(p-nitrobenzyl)oxy]carbonyl}-1H-benzotriazole 
• 53179-09-2 Sisomicin sulfate 
• 1154758-31-2 N-(4-nitrobenzyl carbonate)bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid imide 
• 24424-99-5 di-tert-butyl dicarbonate 
• 69888-89-7 2,5-dioxopyrrolidin-1-yl (4-nitrobenzyl) carbonate 
• 13139-12-3 tert-butyl 2,5-dioxopyrrolidin-1-yl carbonate 
• 32385-11-8 sisomicin 
• 193269-82-8 (N-hydroxy-5-norbomene-2,3-dicarboxylimido)-4-nitrobenzyl carbonate 
• 4457-32-3 4-nitrobenzyl chloroformate 

Downstream Products

• 1154761-11-1 6'-PNZ-2',3-diBoc-1-Fmoc-sisomicin 
• 1154758-59-4 6'-PNZ-2',3,3''-triBoc-sisomicin 
• 1154759-21-3 6'-PNZ-2',3,3''-triBoc-1-(2-hydroxy-acetyl)-sisomicin 
• 1154758-60-7 6'-PNZ-2',3,3''-triBoc-1-(N-Boc-3-amino-2(S)-hydroxy-propionyl)-sisomicin 
• 1154758-62-9 tert-butyl ((2R,3R,4R,5R)-2-(((1S,2S,3R,4S,6R)-4-((tert-butoxycarbonyl)amino)-6-((S)-4-((tert-butoxycarbonyl)amino)-2-hydroxybutanamido)-3-(((2S,3R)-3-((tert-butoxycarbonyl)amino)-6-(((((4-nitrobenzyl)oxy)carbonyl)amino)methyl)-3,4-dihydro-2H-pyran-2-yl)oxy)-2-hydroxycyclohexyl)oxy)-3,5-dihydroxy-5-methyltetrahydro-2H-pyran-4-yl)(methyl)carbamate 
• 1154758-58-3 6'-PNZ-2',3,3''-triBoc-1-Fmoc-sisomicin 
• 1154759-28-0 6'-PNZ-2',3,3''-triBoc-1-(N-phthalimido-2-amino-ethylsulfonamide)-sisomicin 
• 1154758-63-0 tert-butyl ((2R,3R,4R,5R)-2-(((1S,2S,3R,4S,6R)-3-(((2S,3R)-6-(aminomethyl)-3-((tert-butoxycarbonyl)amino)-3,4-dihydro-2H-pyran-2-yl)oxy)-4-((tert-butoxycarbonyl)amino)-6-((S)-4-((tert-butoxycarbonyl)amino)-2-hydroxybutanamido)-2-hydroxycyclohexyl)oxy)-3,5-dihydroxy-5-methyltetrahydro-2H-pyran-4-yl)(methyl)carbamate 
• 1154758-61-8 2',3,3''-triBoc-1-(N-Boc-3-amino-2(S)-hydroxy-propionyl)-sisomicin 

Relevant articles and documents

Synthesis method of plazomicin or salt of plazomicin

The invention relates to a synthesis method of plazomicin or salt of the plazomicin. Specifically, the synthesis method uses a compound 6 as a raw material, six steps of exchange reaction, amino protection reaction, PNZ protecting group removal reaction, reductive amination reaction, degradation reaction and amino-protecting group removal reaction are sequentially performed, and finally the plazomicin or the salt of the plazomicin is prepared. The details of specific steps are described in the description. The synthesis method has the advantages of being few in steps, high in reaction selectivity, simple in operation, low in material cost and the like, and is very suitable for industrial application.

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