698975-01-8Relevant academic research and scientific papers
Singlet oxygen mediated dual C-C and C-N bond cleavage in visible light
Jain, Nidhi,Kumar, Sharvan,Ritu,Sharma, Charu
, p. 2921 - 2928 (2020/04/28)
A tandem cleavage of carbon-carbon and carbon-nitrogen bonds in imidazo[1,2-a]pyridines and imidazo[1,2-a]quinolines is reported in the presence of eosin Y and visible light. The ring opening occurs under ambient conditions through singlet oxygen insertio
Transition-metal free C3-amidation of quinoxalin-2(1: H)-ones using Selectfluor as a mild oxidant
Yuan, Jin-Wei,Zhu, Jun-Liang,Li, Bing,Yang, Liang-Yu,Mao, Pu,Zhang, Shou-Ren,Li, Yan-Chun,Qu, Ling-Bo
, p. 10178 - 10187 (2019/12/26)
A practical and efficient synthetic route to construct a variety of 3-amidated quinoxalin-2(1H)-ones was developed via transition-metal free direct oxidative amidation of quinoxalin-2(1H)-ones with amidates using Selectfluor reagent as a mild oxidant. This protocol features mild reaction conditions, operational simplicity, broad substrate scope, and good to excellent yields.
Copper(II)-mediated, carbon degradation-based amidation of phenylacetic acids toward N -substituted benzamides
Deng, Leiling,Huang, Bin,Liu, Yunyun
supporting information, p. 1552 - 1556 (2018/03/08)
The unprecedented synthesis of N-aryl substituted benzamides via the assembly of primary amines and phenylacetic acids has been developed in the presence of copper(ii) acetate. This tandem transformation involving carbon-carbon bond cleavage provides a complementary tool with particular application in the synthesis of secondary benzamides.
TsOH·H2O-mediated: N -amidation of quinoline N -oxides: Facile and regioselective synthesis of N -(quinolin-2-yl)amides
Chen, Xinghua,Peng, Mei,Huang, Hao,Zheng, Yangfan,Tao, Xiaojun,He, Chunlian,Xiao, Yi
supporting information, p. 6202 - 6205 (2018/09/10)
An operationally simple method with 100% atom economy has been developed for the synthesis of various N-(quinolin-2-yl)amides via the TsOH·H2O-mediated N-amidation of quinoline N-oxides using inexpensive and commercially available nitriles as the amidation reagents. Mechanistic exploration suggested that the reaction probably proceeds through an acid-assisted 1,3-dipolar cycloaddition and an N-O bond cleavage followed by a dehydro-aromatization process.
