698983-69-6Relevant academic research and scientific papers
6-[2-(4-Aryl-1-piperazinyl)ethyl]-2H-1,4-benzoxazin-3(4H)-ones: Dual-acting 5-HT1 receptor antagonists and serotonin reuptake inhibitors
Bromidge, Steven M.,Bertani, Barbara,Borriello, Manuela,Faedo, Stefania,Gordon, Laurie J.,Granci, Enrica,Hill, Matthew,Marshall, Howard R.,Stasi, Luigi P.,Zucchelli, Valeria,Merlo, Giancarlo,Vesentini, Alessia,Watson, Jeannette M.,Zonzini, Laura
scheme or table, p. 5653 - 5656 (2009/06/30)
Investigation of a series 6-[2-(4-aryl-1-piperazinyl)ethyl]-2H-1,4-benzoxazin-3(4H)-ones has led to the discovery of potent 5-HT1A/1B/1D receptor antagonists with and without additional SerT affinity. Modulation of the different target activities gave compounds with a range of profiles suitable for further in vivo characterization.
BENZOXAZINONE DERIVATIVES, PREPARATION THEREOF AND USES IN THE TREATMENT OF CNS AND OTHER DISORDERS
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Page 37, (2008/06/13)
Compounds of formula (I) and pharmaceutically acceptable salts thereof are disclosed:wherein A, R1, R2, R3, p, q, A and X are as defined in the specification. Preparation of the compounds and uses in the treatment of CNS and other disorders, including dep
