699010-06-5

Upstream product

• 63131-29-3 methyl 4-fluorobenzoyl acetate 
• 60-34-4 methylhydrazine 
• 42122-44-1 methyl 3-(4-fluorophenyl)propiolate 

Downstream Products

• 699010-07-6 1,1,2,2,3,3,4,4,4-nonafluoro-butane-1-sulfonic acid 5-(4-fluoro-phenyl)-2-methyl-2H-pyrazol-3-yl ester 

Relevant academic research and scientific papers

PYRAZOLONE DERIVATIVES AS NITROXYL DONORS

The disclosed subject matter provides pyrazolone derivative compounds, pharmaceutical compositions comprising such compounds, kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of using such compounds or pharmaceutical compositions for treating heart failure.

SUBSTITUTED AZOLE COMPOUNDS AND THEREOF PREPARATION AND APPLICATION

The invention relates to fungicide and insecticide, especifically to the substituted azole compounds and its preparation method and use thereof. The azole compounds of the invention having general formula (I): The compounds of present invention, having br

Regioselective rapid analogue syntheses of 1-methyl-3,5-diarylpyrazoles via palladium-catalysed coupling to 3(5)-pyrazolyl nonaflates

Regioselective rapid analogue syntheses of 1-methyl-3,5-diarylpyrazoles were developed, based on Pd-catalysed couplings to 1-methyl-3(5)-arylpyrazole nonaflates, which offered an advantage in hydrolytic stability over the corresponding triflates. The new bifunctional reagent 1-methyl-3-bromo-pyrazol- 5-yl nonaflate underwent highly chemoselective Pd-catalysed couplings to the nonaflate, followed by Suzuki couplings to the bromide, allowing sequential, regioselective introduction of the two aryl substituents.