BUTTPARK 25\07-09

Base Information

• Chemical Name: BUTTPARK 25\07-09
• CAS No.: 699010-06-5
• Molecular Formula: C₁₀H₉FN₂O
• Molecular Weight: 192.193
• Mol file: 699010-06-5.mol

Synonyms:3-(4-fluorophenyl)-1-methyl-1H-pyrazol-5-ol

Chemical Property of BUTTPARK 25\07-09

Chemical Property:

Purity/Quality:

2,4-DIHYDRO-5-(4-FLUOROPHENYL)-2-METHYL-3H-PYRAZOL-3-ONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of BUTTPARK 25\07-09

There total 4 articles about BUTTPARK 25\07-09 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

methyl 4-fluorobenzoyl acetate (63131-29-3) + methylhydrazine (60-34-4) → 3-(4-fluorophenyl)-1-methyl-1H-pyrazol-5-ol (699010-06-5)

Guidance literature:

With ethanol; for 3h; Reflux;

Reference yield: 60.0%

methyl 3-(4-fluorophenyl)propiolate (42122-44-1) + methylhydrazine (60-34-4) → 3-(4-fluorophenyl)-1-methyl-1H-pyrazol-5-ol (699010-06-5) + 5-(4-fluorophenyl)-3-hydroxy-1-methyl-1H-pyrazole (623577-33-3)

Guidance literature:

In ethanol; at 60 ℃; for 7h;

DOI:10.1055/s-2004-820020

Reference yield:

methyl 4-fluorobenzoyl acetate (63131-29-3) → 3-(4-fluorophenyl)-1-methyl-1H-pyrazol-5-ol (699010-06-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / Ph₃PO; (CF₃CO)2O; Et₃N / 1,2-dichloro-ethane / Heating

2: aq. ethanol / 7 h / 60 °C

With triethylamine; Triphenylphosphine oxide; trifluoroacetic anhydride; In ethanol; 1,2-dichloro-ethane;

DOI:10.1055/s-2004-820020

upstream raw materials:

methyl 3-(4-fluorophenyl)propiolate

methylhydrazine

methyl 4-fluorobenzoyl acetate

Downstream raw materials:

1,1,2,2,3,3,4,4,4-nonafluoro-butane-1-sulfonic acid 5-(4-fluoro-phenyl)-2-methyl-2H-pyrazol-3-yl ester