69917-69-7Relevant academic research and scientific papers
Shapiro reaction in the series of piperidine derivatives. Synthesis of 3-hydroxy-1,2,3,6-tetrahydropyridines
Zvonok,Okaev
, p. 310 - 312 (1996)
It is shown that the reaction of tosylhydrazones of 3-hydroxypiperidin-4-ones with bases, depending on the nature of the latter, results in a rearrangement with a narrowing of the heterocycle and formation of acetylpyrrolidines, or in the formation of 3-h
CARBON-CARBON BOND FORMATION UNDER MILD CONDITIONS VIA TANDEM CATIONIC AZA-COPE REARRANGEMENT-MANNICH REACTIONS. A CONVENIENT SYNTHESIS OF POLYSUBSTITUTED PYRROLIDINES.
Overman,Kakimoto,Okazaki,Meier G. Patrick
, p. 6622 - 6629 (2007/10/02)
The reaction of aldehydes (or ketones) with 2-alkoxy(or hydroxy)-3-alkenamines achieves a general and high-yielding synthesis of polysubstituted 3-acylpyrrolidines (eq 5-9). This tandem cationic aza-Cope rearrangement-Mannich cyclization reaction (eq 1) o
