69917-78-8Relevant academic research and scientific papers
A facile synthesis of N-benzyl-4-acetylproline via a tandem cationic aza-Cope rearrangement-Mannich reaction
Cooke, Andrew,Bennett, Jonathan,McDaid, Emma
, p. 903 - 905 (2002)
N-Benzyl-4-acetylproline can be prepared from N-(2-hydroxy-2-methyl)but-3-enyl-N-benzylamine and glyoxylic acid via a tandem cationic aza-Cope rearrangement-Mannich reaction. This reaction represents the first example of such a mechanism being utilised fo
Regioselectivity in a highly efficient, microwave-assisted epoxide aminolysis
Desai, Hinal,D'Souza, Brendan R.,Foether, Devin,Johnson, Benjamin F.,Lindsay, Harriet A.
, p. 902 - 910 (2008/01/06)
We have developed a microwave-assisted aminolysis of epoxides as an efficient method for synthesizing a number of β-amino alcohols. In most cases, including in reactions of amines with a trisubstituted epoxide, only one equivalent of amine is required to
Palladium(2+)-Catalyzed Intramolecular Aminocarbonylation of 3-Hydroxy-4-pentenylamines and 4-Hydroxy-5-hexenylamines
Tamaru, Yoshinao,Hojo, Makoto,Yoshida, Zen-ichi
, p. 5731 - 5741 (2007/10/02)
Palladium(2+) salt, in the presence of CuCl2 as an oxidant, catalyzes an intramolecular aminocarbonylation of N-protected 3-hydroxy-4-pentenylamines under 1 atm of carbon monoxide and selectively provides cis-3-hydroxypyrrolidine-2-acetic acid lactones.N-
CARBON-CARBON BOND FORMATION UNDER MILD CONDITIONS VIA TANDEM CATIONIC AZA-COPE REARRANGEMENT-MANNICH REACTIONS. A CONVENIENT SYNTHESIS OF POLYSUBSTITUTED PYRROLIDINES.
Overman,Kakimoto,Okazaki,Meier G. Patrick
, p. 6622 - 6629 (2007/10/02)
The reaction of aldehydes (or ketones) with 2-alkoxy(or hydroxy)-3-alkenamines achieves a general and high-yielding synthesis of polysubstituted 3-acylpyrrolidines (eq 5-9). This tandem cationic aza-Cope rearrangement-Mannich cyclization reaction (eq 1) o
