69937-13-9

Basic information

• Product Name: N,N-DIMETHYL-5-NITROTRYPTAMINE
• Synonyms: N,N-DIMETHYL-5-NITROTRYPTAMINE;3-(2-DIMETHYLAMINOETHYL)-5-NITROINDOLE
• CAS NO: 69937-13-9
• Molecular Formula: C12H15N3O2
• Molecular Weight: 233.27
• Product Categories: Amino Acids 13C, 2H, 15N;Amino Acids & Derivatives;Heterocycles;Indole Derivatives
• Mol File: 69937-13-9.mol
• Article Data: 4

Chemical Properties

• Melting Point: 166-169°C
• Appearance: /
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform, Dichloromethane, Methanol
• CAS DataBase Reference: N,N-DIMETHYL-5-NITROTRYPTAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-DIMETHYL-5-NITROTRYPTAMINE(69937-13-9)
• EPA Substance Registry System: N,N-DIMETHYL-5-NITROTRYPTAMINE(69937-13-9)

Safety Data

• Hazardous Substances Data: 69937-13-9(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Solid

Upstream product

• 166171-97-7 3-(2-bromoethyl)-5-nitro-1H-indole 
• 6953-35-1 2-(5-nitro-1H-indol-3-yl)-2-oxoacetyl chloride 
• 6146-52-7 5-nitroindole 
• 122110-09-2 5-nitroindole-3-N,N-dimethylglyoxamide 
• 858231-11-5 3-(2-chloro-ethyl)-5-nitro-indole 
• 124-40-3 dimethyl amine 

Downstream Products

• 99505-03-0 5-amino-3-(2-dimethylaminoethyl)-1H-indol 

Relevant articles and documents

5-arylindole derivatives

Compounds of formula (I), wherein R 1 is (a), (b), (c) or (d); n is 0, 1 or 2; A, B, C and D are each independently nitrogen or carbon; R 2, R 3, R 4 and R 5 are each independently hydrogen, C 1 to C 6 alkyl, aryl, C 1 to C 3 alkyl-aryl, halogen (e.g. fluorine, chlorine, bromine or iodine), cyano, nitro, --(CH 2) m NR 14 R 15, --(CH 2) m OR 9, --SR 9, --SO 2 NR 14 R 15, --(CH 2) m NR 14 SO 2 R 15 --(CH 2) m NR 14 CO 2 R 9, --(CH 2) m NR 14 COR 9, --(CH 2) m NR 14 CONHR 9, --CONR 14 R 15, or --CO 2 R 9 ; R 2 and R 3, R 3 and R 4, or R 4 and R 5 may be taken together to form a five- to seven-membered alkyl ring, a six-membered aryl ring, a five- to seven-membered heteroalkyl ring having 1 heteroatom of N, O, or S, or a five- to six-membered heteroaryl ring having H 1 or 2 heteroatoms of N, O, or S and the pharmaceutically acceptable salts thereof. These compounds are useful in treating migraine and other disorders. These compounds are useful psychotherapeutics and are potent serotonin (5-HT 1) agonists and benzodiazepine agonists and antagonists and may be used in the treatment of depression, anxiety, eating disorders, obesity, drug abuse, cluster headache, migraine, pain and chronic paroxysmal hemicrania and headache associated with vascular disorders, and other disorders arising from deficient serotonergic neurotransmission. The compounds can also be used as centrally acting antihypertensives and vosodilators. STR1

ANTIMIGRAINE CYCLOBUTENEDIONE DERIVATIVES OF TRYPTAMINES

A series of serotonergic 5-cyclobutenedionylamino-substituted tryptamine derivatives of Formula I is disclosed for use in the alleviation of vascular headaches. STR1 The formula I substituents, as further defined in the specification, are: R 1 is hydrogen, halogen, and alkyl; R 2 and R 3 can be hydrogen or alkyl; R 4 is hydrogen, alkyl, acyl or alkylsulfonyl; m is 0 to 3 and n is 1 to 5; and X is amino, alkoxy, hydrogen, alkyl, aryl or alkylaryl.