69948-54-5Relevant articles and documents
Regioselective alkylations of cyclic 1,3-diketones via metalated dimethylhydrazones
Demir, Ayhan S.,Enders, Dieter
, p. 553 - 563 (1997)
Cyclic 1,3- diketones 1 are transformed into their 2,2-dimethylhydrazones 2, which can be alkylated regioselectively at different positions after mono-, di-, tri-, and tetrametalation. Monometalated C-2 unsubstituted hydrazones afford C-2 and N- alkylation, monometalated C-2 substituted hydrazones afford only C-2 alkylation.The regioselectivity of the alkylation of the polymetalated hydrazones follows Hauser's rule according to the sequence: NH- > C-4 Ha > C-5 > C-4 Hb. Hydrolysis of the product hydrazones 3-5 afforded mono- and polyalkylated 1,3- diketones 7 in good yields.
Synthesis of Bicyclic and Tricyclic Enones via Regioselektive Dialkylation of Cyclic 1,3-Diketone-dimethylhydrazones with 4-Chlorobutane-2-one
Demir, Ayhan S.,Enders, Dieter
, p. 834 - 838 (2007/10/02)
An efficient, regioselective synthesis of substituted bicyclo nonenes and decenes of type (4a,b) and the tricyclic tetradecadiene (5) is described.The key step is the regioselective dialkylation of cyclic 1,3-diketone-dimethylhydrazones (1a-e) with 4-chlo
