69961-11-1

Upstream product

• 69942-12-7 N-tert-butoxycarbonylserine methyl ester 
• 98-59-9 p-toluenesulfonyl chloride 
• 95715-85-8 2-(tert-butoxycarbonylamino)-3-hydroxypropionic acid methyl ester 
• 3850-40-6 N-Boc-DL-serine 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 869646-27-5 C₁₆H₂₃NO₄Se 
• 185437-39-2 [Co(NC₅H₅)(CH₂CH(CO₂CH₃)NHCOOC₄H₉)(ONC(C₆H₅)C(C₆H₅)NOH)2] 
• 178261-28-4 Methyl 2-(tert-butoxycarbonylamino)-3-(N-methyl-3,4-dichlorobenzylamino)propionate 
• 178261-29-5 2-(tert-Butoxycarbonylamino)-3-(N-methyl-3,4-dichlorobenzylamino)propionic acid 
• 178261-23-9 Methyl 2-(tert-butoxycarbonylamino)-3-(3,4-dichlorobenzylamino) propionate 
• 851121-87-4 3-[3-benzyloxy-4-methoxy-2-(4-methoxy-benzyloxymethyl)-5-methyl-phenyl]-2-tert-butoxycarbonylamino-acrylic acid methyl ester 
• 55477-80-0 methyl 2-[(tert-butoxycarbonyl)amino]acrylate 
• 145618-64-0 methyl 2-(tert-butoxycarbonylamino) hexanoate 

Relevant academic research and scientific papers

Improved synthetic routes to the selenocysteine derivatives useful for Boc-based peptide synthesis with benzylic protection on the selenium atom

Selenocysteine (Sec) derivatives, i.e., Boc-Sec(MBn)-OH (1) and Boc-Sec(MPM)-OH (2), which are useful for chemical synthesis of selenopeptides, were obtained from L-serine in five steps with total yields of 73% and 74%, respectively. The enantiomeric excesses were confirmed to be >99% e.e. by optical resolution using a chiral column on HPLC. On the other hand, for the case of a Fmoc-protected Sec derivative, i.e., Fmoc-Sec(MPM)-OH, similar reactions resulted in low yields and partial racemization taking place. [PRESENTED EQUATION]

Carbocyclic HIV protease inhibitors

The present invention is concerned with novel HIV protease Inhibitors of formula I as individual isomers, racemates, non-racemic mixtures or mixtures of diastereoisomers; wherein n, R1and R4are as described herein. The compounds of f

Serine derived NK1 antagonists 1: The effect of modifications to the serine substituents

A series of novel serine derived NK1 antagonists is described. The effect of variations in the N-benzyl, O-benzyl and serine groups are used to define the elements which are necessary for binding.

Synthese d'aminoacides cyclopropaniques par reaction du diazoacetate d'ethyle sur des methyleneglycinates N-proteges

We report a synthesis of glutamic acid analogs, 1-aminocyclopropan-1,2-dicarboxylic acid derivatives, by reaction of ethyl diazoacetate with N-protected methylene glycinates in the presence of achiral and chiral copper complexes.The cyclopropanation is effective with these catalysts but the Pfaltz chiral complex did not induce any enantioselectivity.