69961-11-1

Basic information

• Product Name: Serine, N-[(1,1-dimethylethoxy)carbonyl]-, methyl ester, 4-methylbenzenesulfonate (ester)
• CAS NO: 69961-11-1
• Molecular Formula: C16H23NO7S
• Molecular Weight: 373.427
• Mol File: 69961-11-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Serine, N-[(1,1-dimethylethoxy)carbonyl]-, methyl ester, 4-methylbenzenesulfonate (ester)(CAS DataBase Reference)
• NIST Chemistry Reference: Serine, N-[(1,1-dimethylethoxy)carbonyl]-, methyl ester, 4-methylbenzenesulfonate (ester)(69961-11-1)
• EPA Substance Registry System: Serine, N-[(1,1-dimethylethoxy)carbonyl]-, methyl ester, 4-methylbenzenesulfonate (ester)(69961-11-1)

Safety Data

• Hazardous Substances Data: 69961-11-1(Hazardous Substances Data)

Upstream product

• 95715-85-8 2-(tert-butoxycarbonylamino)-3-hydroxypropionic acid methyl ester 
• 98-59-9 p-toluenesulfonyl chloride 
• 3850-40-6 N-Boc-DL-serine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 69942-12-7 N-tert-butoxycarbonylserine methyl ester 

Downstream Products

• 851121-87-4 3-[3-benzyloxy-4-methoxy-2-(4-methoxy-benzyloxymethyl)-5-methyl-phenyl]-2-tert-butoxycarbonylamino-acrylic acid methyl ester 
• 869646-27-5 C₁₆H₂₃NO₄Se 
• 185437-39-2 [Co(NC₅H₅)(CH₂CH(CO₂CH₃)NHCOOC₄H₉)(ONC(C₆H₅)C(C₆H₅)NOH)2] 
• 178261-28-4 Methyl 2-(tert-butoxycarbonylamino)-3-(N-methyl-3,4-dichlorobenzylamino)propionate 
• 178261-29-5 2-(tert-Butoxycarbonylamino)-3-(N-methyl-3,4-dichlorobenzylamino)propionic acid 
• 178261-23-9 Methyl 2-(tert-butoxycarbonylamino)-3-(3,4-dichlorobenzylamino) propionate 
• 55477-80-0 methyl 2-[(tert-butoxycarbonyl)amino]acrylate 
• 145618-64-0 methyl 2-(tert-butoxycarbonylamino) hexanoate 

Relevant articles and documents

Improved synthetic routes to the selenocysteine derivatives useful for Boc-based peptide synthesis with benzylic protection on the selenium atom

Selenocysteine (Sec) derivatives, i.e., Boc-Sec(MBn)-OH (1) and Boc-Sec(MPM)-OH (2), which are useful for chemical synthesis of selenopeptides, were obtained from L-serine in five steps with total yields of 73% and 74%, respectively. The enantiomeric excesses were confirmed to be >99% e.e. by optical resolution using a chiral column on HPLC. On the other hand, for the case of a Fmoc-protected Sec derivative, i.e., Fmoc-Sec(MPM)-OH, similar reactions resulted in low yields and partial racemization taking place. [PRESENTED EQUATION]

Serine derived NK1 antagonists 1: The effect of modifications to the serine substituents

A series of novel serine derived NK1 antagonists is described. The effect of variations in the N-benzyl, O-benzyl and serine groups are used to define the elements which are necessary for binding.