69966-75-2

Upstream product

• 2810-42-6 N,N'-bis(chloroacetyl)-o-phenylenediamine 
• 95-54-5 1,2-diamino-benzene 
• 518038-50-1 o-phenylene-N,N-bis-(2-benzoxycarbonylaminoethanamide) 
• 518038-51-2 o-phenylene-N,N-bis-[2-(fluoren-9-yl)methyloxycarbonylaminoethanamide] 

Downstream Products

• 1146685-13-3 N,N'-(1,2-phenylene)bis(2-(3-phenylthioureido)acetamide) 
• 36799-08-3 o-phenylene-N,N-bis(ethylenediamine) 

Relevant academic research and scientific papers

Tethered thiazolidinone dimers as inhibitors of the bacterial type III secretion system

Disruption of protein-protein interactions by small molecules is achievable but presents significant hurdles for effective compound design. In earlier work we identified a series of thiazolidinone inhibitors of the bacterial type III secretion system (T3SS) and demonstrated that this scaffold had the potential to be expanded into molecules with broad-spectrum anti-Gram negative activity. We now report on one series of thiazolidinone analogs in which the heterocycle is presented as a dimer at the termini of a series of linkers. Many of these dimers inhibited the T3SS-dependent secretion of a virulence protein at concentrations lower than that of the original monomeric compound identified in our screen.

Synthesis and metal complexation properties of Ph-DTPA and Ph-TTHA: Novel radionuclide chelating agents for use in nuclear medicine

We wish to report the synthesis and metal complexation properties of new radionuclide chelating agents for use in nuclear medicine. The strategy includes the facile preparation of rigid analogues of DTPA and TTHA possessing an aromatic ring. The aromatic

Efficient synthesis of a new potential chelating agent for radioimmunotherapy

The synthesis of a new rigid analogue of cyclohexyl-TTHA, an efficient lanthanide ligand, as well, as the first complexation trials are reported. This polyaminopolycarboxylic acid, Ph-DTHA 1, was obtained in five steps from phenylenediamine as starting pr