70-22-4 Usage
Description
Oxotremorine, also known as 1-(-pyrrolidono)-4-pyrrolidino-2-butyne, is a central nervous system (CNS) muscarinic stimulant. It is known for its action on the brain, which produces tremors in experimental animals. Oxotremorine has the ability to increase acetylcholine (ACh) brain levels in rats by up to 40%. It has been studied as a potential drug for the treatment of Alzheimer's disease, with earlier studies suggesting that elevating levels of ACh could be a useful approach. However, this belief has been highly disputed by many researchers.
Uses
Used in Pharmaceutical Research:
Oxotremorine is used as a research compound for studying the effects of muscarinic stimulation on the central nervous system. Its ability to increase ACh levels in the brain makes it a valuable tool for investigating the role of acetylcholine in cognitive function and neurodegenerative diseases.
Used in Alzheimer's Disease Research:
Oxotremorine is used as a potential therapeutic agent in the study and treatment of Alzheimer's disease. It has been explored as a means to elevate ACh levels in the brain, which was initially thought to be a promising approach for managing the disease. However, the effectiveness of this approach remains a subject of debate among researchers.
Used in Toxicological Studies:
Due to its ability to induce tremors in experimental animals, Oxotremorine is also used in toxicological studies to understand the effects of muscarinic stimulation on the nervous system and to develop potential countermeasures or treatments for exposure to similar compounds.
Clinical Use
Nevertheless, oxotremorine, as a cholinergicagonist, facilitates memory storage. These findings haveserved as important leads in the development of agents usefulin treating Alzheimer disease. Although it possessesgroups that do not occur in other highly active muscarinicagents, oxotremorine’s trans conformation shows that distancesbetween possible active centers correspond with (+)-muscarine.
Safety Profile
Poison by ingestion and intraperitoneal routes. Moderately toxic by intravenous route. When heated to decomposition it emits toxic fumes of NOx.
Check Digit Verification of cas no
The CAS Registry Mumber 70-22-4 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 7 and 0 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 70-22:
(4*7)+(3*0)+(2*2)+(1*2)=34
34 % 10 = 4
So 70-22-4 is a valid CAS Registry Number.
InChI:InChI=1/C12H18N2O/c15-12-6-5-11-14(12)10-4-3-9-13-7-1-2-8-13/h1-2,5-11H2
70-22-4Relevant articles and documents
Archibald
, p. 390 (1965)
SPIRO NITROGEN-BRIDGED HETEROCYCLIC COMPOUNDS
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, (2008/06/13)
The invention relates to novel compounds (I) for treating diseases of the central and peripheral nervous system: STR1 including enantiomers, racemates and acid addition and quaternary salts thereof, wherein one of X and Y is O and the other of X and Y is N; Q is (CH 2) n or C(CH. sub.3) 2 where n is 1, 2 or 3 and the bridge--Q--is attached at one end to position 1 and at the other end to position 4 or 5, and R° is hydrogen, methyl or hydroxyl; in the moiety STR2 the line connecting Z and Y signifies a double bond when X--Z is O--C--R and Y is N, and a single bond when X--Z is N=C--R and Y is O; Z is C--R wherein R is selected from hydrogen, NH 2, NH-R" (R"=C 1-6-alkyl) , N(R") 2, R", C 2-6-alkenyl, C 2-6-alkynyl, C 3-7-cycloalkyl, R" substituted by hydroxy or by 1-6 halogen atoms, R"O-C 1-6-alkyl, carboxy-C 1-6-alkyl, R"OCO-C 1-6-alkyl, amino-C 1-6-alkyl, R"NH-C 1-6-alkyl, (R") 2 N-C 1-6-alkyl, 2-oxo-pyrrolidin-1-ylmethyl, aryl, diarylmethylol, and R" substituted by one or two aryl groups, wherein aryl denotes phenyl optionally substituted by 1-3 halogens, R", R"O and(or) CF 3. Also claimed are compounds wherein the line connecting Z and Y signifies the absence of a bond, X is O, Z is H and Y is NH 2, NO 2 or N 3. "
