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766-61-0

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766-61-0 Usage

General Description

1-PROP-2-YNYL-PYRROLIDIN-2-ONE, also known as 1-ethynyl-2-pyrrolidinone, is a chemical compound with the molecular formula C7H9NO. It is a derivative of pyrrolidinone, with an ethynyl group attached to the 1-position of the pyrrolidinone ring. 1-PROP-2-YNYL-PYRROLIDIN-2-ONE has a wide range of applications, including as a building block for the synthesis of various pharmaceuticals and agrochemicals. It is also used as a reagent in organic synthesis, particularly in the formation of heterocyclic compounds. Additionally, 1-PROP-2-YNYL-PYRROLIDIN-2-ONE has been studied for its potential biological activities, such as anticancer, antifungal, and antibacterial properties. Overall, this chemical compound has significant importance in the fields of medicinal and organic chemistry.

Check Digit Verification of cas no

The CAS Registry Mumber 766-61-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 7,6 and 6 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 766-61:
(5*7)+(4*6)+(3*6)+(2*6)+(1*1)=90
90 % 10 = 0
So 766-61-0 is a valid CAS Registry Number.

766-61-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-prop-2-ynylpyrrolidin-2-one

1.2 Other means of identification

Product number -
Other names propargylpyrrolidinone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:766-61-0 SDS

766-61-0Relevant articles and documents

Nickel-catalyzed synthesis of stereochemically defined enamides via Bi- and tricomponent coupling reaction

Liu,De Nisi,Cerveri,Monari,Bandini

supporting information, p. 5034 - 5037 (2017/11/06)

The stereoselective synthesis of (E)-trisubstituted tertiary enamides is documented via site-selective Ni-catalyzed β-arylation of allenamides with boronic acids in high yields (up to 89%). The nucleophilic character of the "organo-Ni" intermediates is further exploited to implement a one-pot tricomponent procedure involving the final allylation of aldehydes (yields up to 93%). Mechanistic insights and efficiency on a gram scale process were also documented.

Isoxazoline, isoxazole, and oxadiazole derivatives as M1 muscarinic acetylcholine receptor agonists

Muthusamy, Selvaraj,Lee, Soo Min,Huang, Minghua,Cho, Nam-Chul,Nam, Ghilsoo,Pae, Ae Nim,Rhim, Hyewhon,Keum, Gyochang,Choi, Kyung Il

supporting information, p. 1020 - 1028 (2016/07/15)

Insertion of a methylene linker between the 2-pyrrolidinone substituent and the isoxazoline core of the lead compound 1 previously reported resulted in the loss of its agonistic activity. One exception was the compound 6f having oxadiazole core and 2-azabicyclo[2.2.1]heptane substituent. Of the two isomers of 6f, exo-isomer (EC50 0.013 μM) was five-to six-fold more effective than endo-isomer (EC50 0.30 μM), and ca. two-fold active than the mother compound 1 (EC50 0.031 μM) in stimulating the M1 mAChR. Both isomers were moderately selective agonists for M1 mAChR over the rest four subtypes, and it could be explained by docking study on active conformation allosteric binding sites of M1-M5 mAChRs and calculating their binding energies.

On the base-induced isomerization of cyclic propargylamides to cyclic allenamides

Fenández, Israel,Monterde, María I.,Plumet, Joaquín

, p. 6029 - 6031 (2007/10/03)

The reaction of lactams 4 (n = 1-5) with propargyl bromide affords propargylamides or allenylamides depending on the ring-size. Theoretical calculations support the dependence of the extension of the isomerization on the ring-size.

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