70010-33-2

Basic information

• Product Name: 1H-indazol-3-ol
• CAS NO: 70010-33-2
• Molecular Weight: 134.137
• Mol File: 70010-33-2.mol

Chemical Properties

• CAS DataBase Reference: 1H-indazol-3-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-indazol-3-ol(70010-33-2)
• EPA Substance Registry System: 1H-indazol-3-ol(70010-33-2)

Safety Data

• Hazardous Substances Data: 70010-33-2(Hazardous Substances Data)

Upstream product

• 936-02-7 2-Hydroxybenzoylhydrazine 
• 118-92-3 anthranilic acid 
• 5326-27-2 2-hydrazino-benzoic acid 
• 33906-30-8 2-hydrazinobenzoic acid hydrochloride 

Downstream Products

• 602280-13-7 ethyl 5-{[3-(benzyloxy)-1H-indazol-1-yl]methyl}-2-furoate 
• 1300727-47-2 1-benzyl-3-difluoromethoxy-1H-indazole 
• 1300727-48-3 1-benzyl-2-difluoromethyl-1,2-dihydro-3H-indazol-3-one 
• 1300727-49-4 1-benzyl-3-(2-bromo-1,1,2,2-tetrafluoroethoxy)-1H-indazole 
• 1300727-50-7 1-benzyl-3-(2,2-dichloro-1,1,2-trifluoroethoxy)-1H-indazole 
• 1300727-58-5 1-benzyl-3-(1,1,2,2-tetrafluoroethoxy)-1H-indazole 
• 1300727-54-1 1-benzyl-3-(2-chloro-1,1,2-trifluoroethoxy)-1H-indazole 
• 1300727-55-2 1-benzyl-3-(1-fluorovinyloxy)-1H-indazole 
• 1300727-56-3 1-benzyl-3-(1,1-difluoroethoxy)-1H-indazole 
• 2215-63-6 1-benzyl-3-hydroxy-1H-indazole 
• 1300727-59-6 1-(p-methoxybenzyl)-3-(1,1,2,2-tetrafluoroethoxy)-1H-indazole 
• 1029-30-7 1-(p-methoxybenzyl)-1H-indazol-3-ol 
• 1848-41-5 3-methoxy-1H-indazole 

Relevant articles and documents

Discovery of isatin and 1H-indazol-3-ol derivatives as D-amino acid oxidase (DAAO) inhibitors

D-Amino acid oxidase (DAAO) is a potential target in the treatment of schizophrenia as its inhibition increases brain D-serine level and thus contributes to NMDA receptor activation. Inhibitors of DAAO were sought testing [6+5] type heterocycles and identified isatin derivatives as micromolar DAAO inhibitors. A pharmacophore and structure-activity relationship analysis of isatins and reported DAAO inhibitors led us to investigate 1H-indazol-3-ol derivatives and nanomolar inhibitors were identified. The series was further characterized by pKa and isothermal titration calorimetry measurements. Representative compounds exhibited beneficial properties in in vitro metabolic stability and PAMPA assays. 6-fluoro-1H-indazol-3-ol (37) significantly increased plasma D-serine level in an in vivo study on mice. These results show that the 1H-indazol-3-ol series represents a novel class of DAAO inhibitors with the potential to develop drug candidates.

Method for preparing 1-benzyl-3-hydroxy-1H-3-indazole sodium salt

The invention relates to a method for preparing 1-benzyl-3-hydroxy-1H-3-indazole sodium salt. The method is characterized in that o-aminobenzoic acid, concentrated hydrochloric acid, a NaNO2 solution and solid Na2SO3 are taken as starting raw materials, a proper amount of a NaOH solution and a proper amount of benzyl chloride are added, and 1-benzyl-3-hydroxy-1H-3-indazole sodium salt is obtained through multi-step reaction filtering dehydration. The method is easily accessible in raw material, mild in reaction condition, low in cost and suitable for factory large-scale production.