70010-49-0

Upstream product

• 6165-68-0 thiophene boronic acid 
• 106-40-1 4-bromo-aniline 
• 100-19-6 (4-nitrophenyl)ethanone 
• 108791-66-8 1,4‐bis(4‐nitrophenyl)butane‐1,4‐dione 
• 74812-79-6 1-(4-nitrophenyl)-1-trimethylsilyloxyethylene 
• 24067-17-2 4-nitrophenylboronic acid 
• 586-78-7 para-nitrophenyl bromide 
• 70010-47-8 2,5-bis(4-nitrophenyl)thiophene 
• 63574-85-6 2,5-Bis(p-bromophenyl)thiophene 
• 2461-83-8 1,4-bis(4-bromophenyl)-1,4-butanedione 

Downstream Products

• 1313744-09-0 (2S,2'S)-N,N'-(2,5-thienediyldi-4,1-phenylene)bis(1-(phenylacetyl)-2-pyrrolidinecarboxamide) 
• 939792-43-5 C₃₈H₃₈N₆O₄S 
• 939792-42-4 C₃₆H₃₄N₆O₄S 
• 939792-41-3 2,5-bis[4-(N'-ethoxycarbonyl-N''-cyclohexylguanidino)phenyl]thiophene 
• 939792-40-2 C₃₄H₄₂N₆O₄S 
• 939792-39-9 2,5-bis[4-(N'-ethoxycarbonyl-N''-isopropylguanidino)phenyl]thiophene 
• 939792-38-8 2,5-bis[4-(N'-ethoxycarbonyl-N''-methylguanidino)phenyl]thiophene 
• 939792-37-7 2,5-bis[4-(N'-ethoxycarbonylthioureido)phenyl]thiophene 
• 423165-73-5 C₃₈H₅₀N₆O₈S 

Relevant academic research and scientific papers

A porphyrin porous organic polymer with bicatalytic sites for highly efficient one-pot tandem catalysis

A novel porphyrin-based porous organic polymer PPOP-1(Pd) with bifunctional catalytic sites was constructed via imine condensation of tetra(4-aminophenyl)porphyrin and acenaphthenequinone. PPOP-1(Pd) containing Pd(ii)-porphyrin and Pd(ii)-α-diimine moieties exhibits excellent catalytic activity and outstanding reusability for tandem catalytic reactions of C-H arylation and Suzuki coupling.

Elicitation effects of a synthetic 1,2,4,5-tetraoxane and a 2,5-diphenylthiophene in shoot cultures of two Nepeta species

The presented study aimed to investigate the elicitation possibility for the production of main secondary metabolites in Nepeta cataria L. and N. pannonica L. plants, by exposing them to synthetic compounds belonging to tetraoxanes and thiophenes group. The effect of DO63 (1,2,4,5-tetraoxane) and DOVF15 (2,5-diphenylthiophene) on the production of cis-trans-nepetalactone (NL) and rosmarinic acid (RA) in two Nepeta species, was investigated in shoots grown on the culture medium with the addition of synthetic compounds in the concentrations ranging from 0.1 to 2 mg L-1. The content of targeted metabolites in tested in vitro shoots depended on the type and concentration of applied synthetic compounds. Application of DO63 in the concentration range 0.1-1 mg L-1 affected only NL production in both Nepeta species resulting in its increased content, while production of RA was not influenced in the treated shoots. Addition of DOVF15 caused decreased RA content in N. pannonica shoots and an increase in N. cataria shoots, whereas NL production was not affected. The presented results reveal the possibility of DO63 and DOVF15 application for the elicitation of the main secondary metabolites production in species from the genus Nepeta.

HCV NS5A replication complex inhibitors. Part 3

In a recent disclosure,1 we described the discovery of dimeric, prolinamide-based NS5A replication complex inhibitors exhibiting excellent potency towards an HCV genotype 1b replicon. That disclosure dealt with the SAR exploration of the peripheral region of our lead chemotype, and herein is described the SAR uncovered from a complementary effort that focused on the central core region. From this effort, the contribution of the core region to the overall topology of the pharmacophore, primarily vector orientation and planarity, was determined, with a set of analogs exhibiting 50 in a genotype 1b replicon assay.

HEPATITIS C VIRUS INHIBITORS

The present disclosure is generally directed to antiviral compounds, and more specifically directed to compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such compounds, and methods for inhibiting the function of the NS5A protein

Synthesis and antiparasitic evaluation of bis-2,5-[4-guanidinophenyl]thiophenes

A series of bis-2,5-[4-guanidinophenyl]thiophenes were prepared in a five step process starting from 2,5-bis[trimethylstannyl]thiophene. The compounds were evaluated in vitro against Trypanosoma brucei rhodesiense (T. b. r.), Plasmodium falciparum (P. f.)

Design, synthesis, and structure-activity relationship of novel thiophene derivatives for β-amyloid plaque imaging

Novel 2,5-diphenylthiophene derivatives were synthesized and structure activity relationship with regard to Aβ plaque binding was studied. Binding affinities of these compounds were found to range from 3.9 to >1000 nM, depending on the substitution patter

Models for intramolecular exchange in organic π-conjugated open-shell systems: 3-Nitrenophenyl and 4-nitrenophenyl units connected by 2,5-furandiyl, 2,5-thiophenediyl, and 2,5-pyrrolediyl nonalternant exchange linkers

The first bis(arylnitrenes) linked by heterocyclic pseudoaromatic rings were generated in a glassy, 77 K 2-methyltetrahydrofuran matrix by photolysis at wavelengths >300 nm: 2,5-bis(3-nitrenophenyl)furan (1); 2,5-bis-(3-nitrenophenyl)thiophene (2); 2,5-bi