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Usage

Uses

1. Used in Pharmaceutical Industry:
1,4-Bis(4-bromophenyl)butane-1,4-dione is used as an intermediate in the synthesis of Furamidine (F863600), which is an antimicrobial and antiparasitic agent. Its role in the preparation of Furamidine is crucial due to its unique chemical properties that facilitate the formation of the desired active pharmaceutical ingredient.
2. Used in Chemical Synthesis:
1,4-Bis(4-bromophenyl)butane-1,4-dione serves as a versatile building block in the synthesis of various organic compounds, particularly those with potential applications in the pharmaceutical, agrochemical, and materials science industries. Its reactivity and stability make it a valuable component in the development of new molecules with specific biological activities or material properties.

InChI:InChI=1/C16H12Br2O2/c17-13-5-1-11(2-6-13)15(19)9-10-16(20)12-3-7-14(18)8-4-12/h1-8H,9-10H2

Upstream product

• 165287-54-7 2,3-dibromo-1,4-bis-(4-bromo-phenyl)-butane-1,4-dione 
• 534-22-5 2-methylfuran 
• 1861-48-9 dithiocarbonic acid S-[2-(4-bromo-phenyl)-2-oxo-ethyl] ester O-ethyl ester 
• 67-68-5 dimethyl sulfoxide 
• 81585-72-0 1-(4-bromo-phenyl)-2-iodo-ethanone 
• 99-73-0 para-bromophenacyl bromide 
• 41024-55-9 1-(4-bromophenyl)-2-(phenylsulfonyl)ethanone 
• 34102-91-5 1,4-bis-(4-bromo-phenyl)-but-2-ene-1,4-dione 
• 132665-87-3 1,4-bis-(4-bromo-phenyl)-but-2-yne-1,4-dione 
• 99-90-1 para-bromoacetophenone 
• 109-89-7 diethylamine 
• 7646-85-7 zinc(II) chloride 
• 75-65-0 tert-butyl alcohol 
• 93298-05-6 C₉H₉Br₂N₃O 

Downstream Products

• 6332-09-8 (E)-1,4-bis(4-bromophenyl)but-2-ene-1,4-dione 
• 61829-88-7 2,5-bis-(4-bromo-phenyl)-3,4-dichloro-furan 
• 91733-25-4 3,4-dibromo-2,5-bis-(4-bromo-phenyl)-furan 
• 1185200-12-7 2,5-bis(4-bromophenyl)-1-phenyl-1H-pyrrole 
• 36710-35-7 2,5-bis(4-bromophenyl)furan 
• 1258232-63-1 2,5-bis(4-bromophenyl)-1-(4-tert-butylphenyl)-1H-pyrrole 
• 947325-91-9 (1R,4R)-1,4-bis(4-bromophenyl)butane-1,4-diol 
• 1258232-64-2 1-(4-tert-butylphenyl)-2,5-bis(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1H-pyrrole 
• 65356-06-1 3,4-bis(bromomethyl)-2,5-bis(4-bromophenyl)furan 

Relevant academic research and scientific papers

Copper(I)/DDQ-Mediated Double-Dehydrogenative Diels-Alder Reaction of Aryl Butenes with 1,4-Diketones and Indolones

A copper(I)/DDQ-mediated double-dehydrogenative Diels-Alder (DDDA) reaction of simple butenes with 1,4-diketones and indolones has been established for the first time. This strategy is based on a tandem double-dehydrogenation/Diels-Alder reaction from nonprefunctionalized starting materials, in which both a diene and dienophile were in situ generated via activation of fourfold inert C(sp3)-H bonds in one catalytic system.

One-Pot Synthesis of O-Heterocycles or Aryl Ketones Using an InCl3/Et3SiH System by Switching the Solvent

An efficient one-pot synthesis of O-heterocycles or aryl ketones has been achieved using Et3SiH in the presence of InCl3 via a sequential ionic hydrogenation reaction by switching the solvent. This methodology can be used to construct C-O bonds and to prepare conjugate reduction products, including chromans, tetrahydrofurans, tetrahydropyrans, dihydroisobenzofurans, dihydrochalcones, and 1,4-diones in a facile manner. In addition, a novel plausible mechanism involving a conjugate reduction and a tandem reductive cyclization was verified by experimental investigations.

Synthesis of 1,4-Diketones via Titanium-Mediated Reductive Homocoupling of α-Haloketones

1,4-Diketones have been synthesized via a reductive homocoupling of α-haloketones. Addition of a Grignard reagent to titanium(IV) isopropoxide affords a low-valent titanium(III) intermediate that is believed to mediate a radical dimerization reaction. The

Facile Synthesis of β-Keto Sulfones Employing Fenton's Reagent in DMSO

A new facile method for the synthesis of β-keto sulfones employing xanthates, DMSO, and Fenton's reagent is described. The reaction proceeds under very mild conditions providing a cost-effective straightforward approach to various β-keto sulfones in high yields.

Synthesis, biological characterisation and structure activity relationships of aromatic bisamidines active against Plasmodium falciparum

Malaria is one of the most significant tropical diseases and remains a major challenge due to the lack of a broadly effective vaccine and parasite resistance to current drugs. This means there is a need for new drug candidates with novel modes of action.

A simple method for the synthesis of furfuryl ketones and furylacetic acid derivatives

A simple preparative method has been developed for the synthesis of aryl(furfuryl) ketones, amides, and furylacetic acid esters, based on radical alkylation of furan derivatives at the α-position with O-ethyl(phenacyl)xanthogenates and phenacyl iodides in the presence of Fenton's reagent (H2O2/FeSO4·7H2O) in DMSO. The range of applicability and mechanisms for the formation of major and side products have been considered.

Visible-light-induced Ci-S bond activation: Facile access to 1,4-diketones from β-ketosulfones

A novel method for the synthesis of 1,4-diketones from β-ketosulfones was developed by means of a visible light-induced Ci￡S bond activation process. Symmetrical and unsymmetrical 1,4-diketones can be easily prepared in moderate to good yields. A new and efficient method for the synthesis of 1,4-diketones from β-ketosulfones was developed by means of a visible-light-induced Ci￡S bond activation process (see scheme). Symmetrical and unsymmetrical 1,4-diketones can be easily prepared in moderate to good yields.

Polymer-stabilized palladium nanoparticles for the chemoselective transfer hydrogenation of α,β-unsaturated carbonyls: Single-step bottom-Up approach

Polypyrrole stabilised palladium nanoparticles show good catalytic efficiency for the chemoselective transfer hydrogenation of α,β- unsaturated carbonyl compounds. The catalyst is very specific and selectively hydrogenates the olefins or acetylenes only,

Woollins reagent: A chemoselective reducing agent for 1,4-enediones and 1,4-ynediones to saturated 1,4-diones

Woollins reagent was found to act as a highly chemoselective reagent for the reduction of a wide range of 1,4-enediones and 1,4-ynediones in methanol to afford the corresponding saturated 1,4-diketones in good yields under mild reaction conditions.

Anti-Viral Compounds

Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.