70027-43-9Relevant articles and documents
Design, synthesis and pharmacological evaluation of carboxamide and carbothioamide derivatives of 1,3,4-thiadiazole as the inhibitors of acetylcholinesterase and oxipiperazine)ative stress for the management of cognitive debility
Kulshreshtha, Akanksha,Piplani, Poonam
, p. 1800 - 1821 (2018/06/18)
Acetylcholinesterase has been a promising target for the development of putative therapeutics against cognitive decline. The deleterious effect of oxidative stress on the learning and memory paradigms of an individual has also been well documented. In vie
Synthesis of 6-Aroylimino-2-aryl-1,3,4-thiadiazolothiadiazolines
Sridevi, G.,Rao, P. Jayaprasad,Reddy, K. Kondal
, p. 997 - 1000 (2007/10/02)
Reaction of 2-amino-5-aryl-1,3,4-thiadiazoles (V) with aroyl isothiocyanates gives 2-aroylamino-5-aryl-1,3,4-thiadiazoles (VII) and N-aroyl-N'-(5-aryl-1,3,4-thiadiazol-2-yl)thioureas (VIII).Contrary to earlier reports, cyclisation of VIII in the presence of PCl5 in POCl3 yields 6-aroylimino-2-aryl-1,3,4-thiadiazolo-thiadiazolines (X).Cyclisation of VIII in the presence of other oxidising agents also leads to X.