700362-32-9

Usage

Uses

Used in Pharmaceutical Industry:
Benzenemethanol, 2-nitro-alpha-(trifluoromethyl)(9CI) is used as an intermediate in the synthesis of pharmaceutical compounds. Its unique structure and functional groups make it a valuable building block for the development of new drugs.
Used in Agrochemical Industry:
In the agrochemical industry, Benzenemethanol, 2-nitro-alpha-(trifluoromethyl)(9CI) is used as a precursor for the synthesis of various agrochemicals, such as pesticides and herbicides. Its properties can contribute to the effectiveness and selectivity of these products.
Used in Organic Synthesis:
Benzenemethanol, 2-nitro-alpha-(trifluoromethyl)(9CI) is utilized as a versatile reagent in organic synthesis. Its nitro and trifluoromethyl groups can be further modified or used as starting points for the synthesis of a wide range of organic compounds.
It is important to handle Benzenemethanol, 2-nitro-alpha-(trifluoromethyl)(9CI) with care, as it may have hazardous properties that can pose risks to human health and the environment. Proper safety measures should be taken during its production, storage, and use to minimize potential hazards.

Upstream product

• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 552-89-6 2-nitro-benzaldehyde 

Downstream Products

• 178042-35-8 1-(4-aminophenyl)-2,2,2-trifluoroethanol 
• 205756-49-6 1,1,1-trifluoro-2-hydroxy-2-(2-aminophenyl)ethane 
• 64196-43-6 2-phenyl-4-(trifluoromethyl)quinoline 
• 17408-17-2 2,2,2-trifluoro-1-(2-nitrophenyl)ethanone 
• 700362-46-5 (2R,3R,4R,5R,6R)-6-Hydroxymethyl-2-p-tolyloxy-5-[2,2,2-trifluoro-1-(2-nitro-phenyl)-ethoxy]-tetrahydro-pyran-3,4-diol 
• 700362-42-1 1-nitro-2-[2,2,2-trifluoro-1-(2-iodo-ethoxy)-ethyl]-benzene 
• 881992-39-8 5-(dimethylamino)naphthalene-1-sulfonic acid [4-(2,2,2-trifluoro-1-hydroxyethyl)phenyl]amide 
• 881992-38-7 5-(dimethylamino)naphthalene-1-sulfonic acid [2-(2,2,2-trifluoro-1-hydroxyethyl)phenyl]amide 

Relevant academic research and scientific papers

Chemoselective Trimerization of Isocyanides: De Novo Synthesis of 2-Indole-Substituted Quinolines and Pyridines

A catalyst-free chemoselective trimerization reaction of readily available isocyanides is described. This domino reaction provides facile access to a wide range of 2-(indol-2-yl)-quinolines and 2-(indol-2-yl)-pyridines in moderate to excellent yields. A “

ALLOSTERIC CHROMENONE INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) FOR THE TREATMENT OF DISEASES ASSOCIATED WITH P13K MODULATION

The disclosure relates to compounds of Formula (I) as allosteric chromenone inhibitors of phosphoinositide 3-kinase (PI3K) useful in the treatment of diseases or disorders associated with PI3K modulation, Formula (I), or a prodrug, solvate, enantiomer, st

Photochemistry of 2-Nitroarenes: 2-Nitrophenyl-α-trifluoromethyl Carbinols as Synthons for Fluoroorganics

Facile synthesis of a new series of 2,2′-bis(trifluoroacetyl) azoxybenzene derivatives and trifluoromethylated benzo[c]isoxazoline systems, along with trifluoroacetyl nitrosobenzene derivatives was achieved by solvent controlled photolysis of appropriate

Oxidation of α-trifluoromethyl and non-fluorinated alcohols: Via the merger of oxoammonium cations and photoredox catalysis

We present an alcohol oxidation strategy to access α-trifluoromethyl ketones (TFMKs) merging catalytic oxoammonium cation oxidation with visible-light photoredox catalysis. This work uses 4-acetamido-(2,2,6,6-tetramethyl-piperidin-1-yl)oxyl as an organic oxidant capable of generating TFMKs in good yields. The methodology serves as an improvement over previous reports of an analogous oxidation strategy requiring superstoichiometric quantities of oxidant. Both primary and secondary non-fluorinated alcohols can also be oxidised in good yields.

Highly efficient synthesis of aryl and heteroaryl trifluoromethyl ketones via o-iodobenzoic acid (IBX)

A two-step process for the synthesis of aryl and heteroaryl trifluoromethyl ketones from the corresponding aldehydes is described. Trifluoromethyl alcohols were prepared from aryl and heteroaryl aldehydes in excellent yields using catalytic amount of K2CO3. The trifluoromethyl alcohols were then oxidized conveniently and efficiently by o-iodoxybenzoic acid (IBX) under mild conditions to get the desired functionalized aryl and heteroaryl trifluoromethyl ketones.

Oxidation of α-trifluoromethyl alcohols using a recyclable oxoammonium salt

A simple, mild method for the oxidation of α-trifluoromethyl alcohols to trifluoromethyl ketones (TFMKs) using the oxoammonium salt 4-acetylamino-2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate (1) is described. Under basic conditions, oxidation proceeds rapidly and affords good to excellent yields of TFMKs, without concomitant formation of the hydrate. The byproduct of the oxidation, 4-acetylamino-2,2,6,6-tetramethyl-1- piperidinyloxy (1c), is easily recovered and can be conveniently reoxidized to regenerate the oxoammonium salt.

Development of fluorination methods using continuous-flow microreactors

The safe and reliable use of various fluorination methods including nucleophilic fluorination (DAST), trifluoromethylation (Ruppert's reagent) and electrophilic fluorination (Selectfluor) in a continuous-flow microreactor is reported. Special a

Fluorescence "turn-on" sensing of carboxylate anions with oligothiophene-based o-(carboxamido)trifluoroacetophenones

(Chemical Equation Presented) o-(Carboxamido)trifluoroacetophenones containing ter- or pentathiophene moiety as a fluorophore exhibit fluorescence enhancement upon binding carboxylate anions. Particularly, the terthiophene derivative shows a large fluorescence enhancement factor (FEF = 120). The enhancement is explained by intramolecular H-bonding stabilization of an anion-ionophore adduct, through which a possible quenching process, the n-π* transition from the trifluoroacetophenone moiety, is eliminated.

Fluorescence modulation in anion sensing by introducing intramolecular H-bonding interactions in host-guest adducts

Fluorescence signaling in anion binding is modulated from quenching to enhancement by intramolecular H-bonding stabilization of anion-ionophore adducts; the intramolecular H-bonding is suggested to suppress the quenching processes otherwise possible and i