70041-48-4

Basic information

• Product Name: 2(3H)-Furanone, 3-[(4-methoxyphenyl)methylene]-5-phenyl-, (3E)-
• CAS NO: 70041-48-4
• Molecular Formula: C18H14O3
• Molecular Weight: 278.307
• Mol File: 70041-48-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2(3H)-Furanone, 3-[(4-methoxyphenyl)methylene]-5-phenyl-, (3E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2(3H)-Furanone, 3-[(4-methoxyphenyl)methylene]-5-phenyl-, (3E)-(70041-48-4)
• EPA Substance Registry System: 2(3H)-Furanone, 3-[(4-methoxyphenyl)methylene]-5-phenyl-, (3E)-(70041-48-4)

Safety Data

• Hazardous Substances Data: 70041-48-4(Hazardous Substances Data)

Upstream product

• 591-50-4 iodobenzene 
• 201230-82-2 carbon monoxide 
• 13540-76-6 3-(4-methoxyphenyl)prop-1-yne 
• 123-11-5 4-methoxy-benzaldehyde 
• 2051-95-8 succinylbenzene 
• 932-88-7 1-iodo-2-phenylethyne 
• 943-89-5 (E)-3-(4-methoxyphenyl)acrylic acid 

Downstream Products

• 74143-87-6 4-(4-Methoxy-phenyl)-1-phenyl-buta-2,3-dien-1-one 

Relevant articles and documents

Stereoselective synthesis of: E -3-(arylmethylidene)-5-(alkyl/aryl)-2(3 H)-furanones by sequential hydroacyloxylation-Mizoroki-Heck reactions of iodoalkynes

A modular, stereoselective synthesis of E-3-(arylidene)-5-(alkyl/aryl)-2(3H)-furanones was developed. The methodology features regioselective addition of β-aryl acrylic acids to iodoacetylenes to furnish the Z-acyloxy iodoalkenes. A stereoselective 5-exo-trig Mizoroki-Heck reaction of the acyloxy iodoalkenes generates the target E-2(3H)-furanones. The approach was applied in a formal synthesis of the naturally occurring kinase inhibitor BE-23372M.

Synthesis of pericarbonyl lignans and their analogues

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