70041-48-4Relevant academic research and scientific papers
Stereoselective synthesis of: E -3-(arylmethylidene)-5-(alkyl/aryl)-2(3 H)-furanones by sequential hydroacyloxylation-Mizoroki-Heck reactions of iodoalkynes
Muthusamy, Gopinathan,Pansare, Sunil V.
, p. 7971 - 7983 (2018/11/21)
A modular, stereoselective synthesis of E-3-(arylidene)-5-(alkyl/aryl)-2(3H)-furanones was developed. The methodology features regioselective addition of β-aryl acrylic acids to iodoacetylenes to furnish the Z-acyloxy iodoalkenes. A stereoselective 5-exo-trig Mizoroki-Heck reaction of the acyloxy iodoalkenes generates the target E-2(3H)-furanones. The approach was applied in a formal synthesis of the naturally occurring kinase inhibitor BE-23372M.
Stereospecific Palladium(II)-Catalyzed Cyclocarbonylation of 3-Aryl-1-propynes and Iodoarenes of Acid Chlorides To Form (E)-3-Arylidenebutenolides
Huang, Yujin,Alper, Howard
, p. 4534 - 4536 (2007/10/02)
Iodoarenes react with 3-aryl-1-propynes and carbon monoxide, in the presence of palladium acetate and triphenylphosphine, to form (E)-arylidenebutenolides in 33-88percent isolated yields.The same product is formed by substitution of acid chloride for a io
