70043-72-0

Upstream product

• 100-39-0 benzyl bromide 
• 19912-56-2 (+/-)-4,4a,5,6,7,8-hexahydro-1-methyl-2-oxo-3H-naphthalene-4a-carbonitrile 
• 342614-31-7 1-Cyan-2-imino-cyclohexan 
• 946-33-8 2-benzylcyclohexan-1-one 
• 1629-58-9 4-penten-3-one 
• 4513-77-3 2-cyanocyclohexanone 
• 646-20-8 pimelonitrile 
• 70043-60-6 6-Benzyl-2-methyl-bicyclo<4.4.0>dec-1-en-3-on 
• 132680-44-5 (+/-)-2-oxo-1-(3-oxopentyl)cyclohexanecarbonitrile 

Relevant academic research and scientific papers

A modified Robinson annulation process to α,α-disubstituted-β,γ-unsaturated cyclohexanone system. Application to the total synthesis of nanaimoal

4-Cyano-2-cyclohexenones were found to be susceptible to reductive alkylation reactions, giving the corresponding 2,2-disubstituted-3-cyclohexenone derivatives in a completely regioselective manner. This newly developed methodology has been successfully applied towards the total synthesis, in racemic form, of the marine natural product nanaimoal.

Reductive alkylation of γ-cyano-α,β-unsaturated ketones. A modified Robinson annulation process to α,α-disubstituted-β,γ-unsaturated cyclohexanone system

Reductive alkylation of various 4-cyano-2-cyclohexenones, readily available from α-cyano ketones via a Robinson annulation process, gave rise to the corresponding 2,2-disubstituted-3-cyclohexenone derivatives in a completely regioselective manner. Application of this methodology resulted in an efficient synthesis of the marine natural product nanaimoal in racemic form.